Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.50 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.47 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29405270 | 0.85 | ALOX5 (0.55) | MAPTPOLBABCC9ABCC8KCNJ11 | |
| SCHEMBL10428298 | 0.84 | SMN1; SMN2 (0.51) | MAPTPOLBHSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL10428429 | 0.80 | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 (0.53) | MAPTPOLBHSP90AA1HSP90AB1RARB | |
| SCHEMBL10428264 | 0.80 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1ABCC9ABCC8KCNJ11 | |
| SCHEMBL11529248 | 0.79 | ALDH1A1 (0.54) | MAPTPOLBABCC9ABCC8KCNJ11 | |
| SCHEMBL10428425 | 0.78 | SIRT1 (0.54) | MAPTPOLBHSP90AA1HSP90AB1ABCC9 | |
| SCHEMBL2786142 | 0.77 | ALDH1A1 (0.50) | MAPTABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL15197122 | 0.77 | ALDH1A1 (0.54) | MAPTABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7367690 | 0.77 | SLC22A6 (0.66) | MAPTPOLBHSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL10428380 | 0.76 | RARB (0.58) | HSP90AA1HSP90AB1ALDH1A1LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4927835-A | ANTIPYRETICS | NIPPON SHINYAKU CO., LTD. (JP) | 1990-05-22 | — | — | US | disclosed |
| EP-0331195-A2 | Acylphenol derivatives | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1989-09-06 | — | — | EP | disclosed |