Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 2/20 | 0.30 |
| ▸ | NOS1 | P29475 | 2/20 | 0.30 |
| ▸ | NOS2 | P35228 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL28801803 | 0.98 | GSR (0.41) | GSRDPP4DPP7DPP8DPP9 | |
| Lysine SCHEMBL29054307 | 0.93 | GSR (0.40) | GSRDPP4DPP7DPP8DPP9 | |
| D-Glutamate SCHEMBL29083846 | 0.92 | GSR (0.33) | GSRCYP1A2 | |
| Lysine SCHEMBL659927 | 0.92 | GSR (0.47) | GSRDPP4DPP7DPP8DPP9 | |
| Lysine SCHEMBL27639977 | 0.92 | GSR (0.47) | GSRDPP4DPP7DPP8DPP9 | |
| Lysine SCHEMBL10481769 | 0.90 | GSR (0.49) | GSRDPP4DPP7DPP8DPP9 | |
| Lysine SCHEMBL5801871 | 0.90 | GSR (0.37) | GSRDPP4DPP7DPP8DPP9 | |
| Lysine SCHEMBL9645760 | 0.89 | GSR (0.40) | GSRDPP4DPP7DPP8DPP9 | |
| Lysine SCHEMBL8205468 | 0.89 | GSR (0.43) | GSRDPP4DPP7DPP8DPP9 | |
| Lysine SCHEMBL17685564 | 0.89 | GSR (0.43) | GSRDPP4DPP7DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0368920-A1 | LECTINES FIXING BETA-D-GALACTOSIDE. | IDEON CORP (US) | 1990-05-23 | — | — | EP | claimed |
| WO-1989000581-A1 | LECTINES FIXING BETA-D-GALACTOSIDE | IDEON CORPORATION (US) | 1989-01-26 | — | — | WO | claimed |
| EP-0368920-A1 | LECTINES FIXING BETA-D-GALACTOSIDE. | IDEON CORP (US) | 1990-05-23 | — | — | EP | disclosed |
| WO-1989000581-A1 | LECTINES FIXING BETA-D-GALACTOSIDE | IDEON CORPORATION (US) | 1989-01-26 | — | — | WO | disclosed |