Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.36 |
| ▸ | DPP4 | P27487 | 4/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | NOS2 | P35228 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ARG1 | P05089 | 3/20 | 0.32 |
| ▸ | ARG2 | P78540 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL27639977 | 1.00 | GSR (0.47) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL17685564 | 0.97 | GSR (0.43) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL8205468 | 0.97 | GSR (0.43) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL28801803 | 0.94 | GSR (0.41) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL4610561 | 0.94 | GSR (0.41) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL29054307 | 0.93 | GSR (0.40) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL10428569 | 0.92 | GSR (0.39) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL3387882 | 0.92 | GSR (0.48) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL21494166 | 0.92 | GSR (0.48) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL21494167 | 0.92 | GSR (0.48) | GSRDPP7DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2196202-B1 | Lys-Pro-Thr and Lys-Pro as inflammation-inhibiting compounds | LUGER THOMAS (DE) | 2013-07-17 | — | — | EP | claimed |
| EP-2198723-B1 | Inflammation inhibiting compounds | LUGER THOMAS (DE) | 2013-04-10 | — | — | EP | claimed |
| EP-1749524-B1 | Inflammation-inhibiting compounds | LUGER THOMAS (DE) | 2011-03-23 | — | — | EP | claimed |
| EP-1427405-B1 | INFLAMMATION-INHIBITING COMPOUNDS | LUGER DR THOMAS (DE) | 2007-04-04 | — | — | EP | claimed |
| US-9987372-B2 | Phosphorylcholine conjugates and uses thereof | TPCERA LTD. (IL) | 2018-06-05 | — | — | US | disclosed |
| US-20170087202-A1 | Inflammation Inhibiting Compounds | LUGER THOMAS (DE) | 2017-03-30 | — | — | US | disclosed |
| US-9550807-B2 | Inflammation inhibiting compounds | LUGER THOMAS (DE) | 2017-01-24 | — | — | US | disclosed |
| US-20160193350-A1 | Phosphorylcholine Conjugates and Uses Thereof | TPCERA LTD. (IL) | 2016-07-07 | — | — | US | disclosed |
| EP-2953978-A1 | PHOSPHORYLCHOLINE CONJUGATES AND USES THEREOF | Tel HaShomer Medical Research Infrastructure and Services Ltd. (IL) | 2015-12-16 | — | — | EP | disclosed |
| US-9156881-B2 | Tripeptide KDPT for antiapoptotic treatment | WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER (DE) | 2015-10-13 | — | — | US | disclosed |
| US-20150087578-A1 | Inflammation Inhibiting Compounds | LUGER THOMAS (DE) | 2015-03-26 | — | — | US | disclosed |
| US-20140323394-A1 | TRIPEPTIDE KDPT FOR ANTIAPOPTOTIC TREATMENT | WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER (DE) | 2014-10-30 | — | — | US | disclosed |
| EP-1117443-B1 | PEPTIDE-BASED CARRIER DEVICES FOR STELLATE CELLS | STICHTING TECH WETENSCHAPP (NL) | 2005-11-02 | — | — | EP | disclosed |
| US-20050227916-A1 | Peptide stellate carrier devices for stellate cells | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2005-10-13 | — | — | US | disclosed |
| US-6844319-B1 | Peptide-based carrier devices for stellate cells | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2005-01-18 | — | — | US | disclosed |
| US-20040077552-A1 | Inflammation-inhibiting compounds | BRZOSKA, THOMAS (DE) | 2004-04-22 | — | — | US | disclosed |
| EP-1117443-A1 | PEPTIDE-BASED CARRIER DEVICES FOR STELLATE CELLS | Stichting voor de Technische Wetenschappen (NL) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000023113-A1 | PEPTIDE-BASED CARRIER DEVICES FOR STELLATE CELLS | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2000-04-27 | — | — | WO | disclosed |
| EP-0825999-A1 | AMINES EXHIBITING ANALGESIC ACTION, THEIR PREPARATION AND USE | L. MOLTENI & C. DEI FRATELLI ALITTI SOCIETA' DI ESERCIZIO SOCIETA' PER AZIONI (IT) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996033210-A1 | AMINES EXHIBITING ANALGESIC ACTION, THEIR PREPARATION AND USE | L. MOLTENI & C. DEI FRATELLI ALITTI - SOCIETA' DI ESERCIZIO SOCIETA' PER AZIONI (IT) | 1996-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170087202-A1 | Inflammation Inhibiting Compounds | ARG1, IL1B, CTSH | GSR 2443/4885DPP7 1088/4885DPP4 1006/4885 |
| US-20040077552-A1 | Inflammation-inhibiting compounds | MIF, MRGPRX2, MRGPRX1 | GSR 2277/4885DPP7 1277/4885DPP4 1360/4885 |
| US-20150087578-A1 | Inflammation Inhibiting Compounds | ARG1, IL1B, CTSH | GSR 2443/4885DPP7 1088/4885DPP4 1006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.