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Lysine

Lysine

SCHEMBL28801803

CC(O)C(N)C(=O)O.NC(=O)CC(N)C(=O)O.NCCCCC(N)C(=O)O.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ GSR P00390 1/20 0.41
▸ DPP7 Q9UHL4 7/20 0.32
▸ DPP4 P27487 4/20 0.32
▸ DPP8 Q6V1X1 3/20 0.32
▸ DPP9 Q86TI2 2/20 0.32
▸ NOS2 P35228 4/20 0.31
▸ NOS1 P29475 3/20 0.31
▸ NOS3 P29474 2/20 0.31
▸ CYP1A2 P05177 1/20 0.31
▸ CYP3A4 P08684 1/20 0.31
▸ TSHR P16473 1/20 0.31
▸ FAP Q12884 1/20 0.31
▸ BLM P54132 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lysine SCHEMBL10428569 0.98 GSR (0.39) GSRDPP7DPP4DPP8DPP9
Lysine SCHEMBL27639977 0.94 GSR (0.47) GSRDPP7DPP4DPP8DPP9
Lysine SCHEMBL659927 0.94 GSR (0.47) GSRDPP7DPP4DPP8DPP9
Lysine SCHEMBL10481769 0.92 GSR (0.49) GSRDPP7DPP4DPP8DPP9
Lysine SCHEMBL29054307 0.91 GSR (0.40) GSRDPP7DPP4DPP8DPP9
Lysine SCHEMBL17685564 0.91 GSR (0.43) GSRDPP7DPP4DPP8DPP9
Lysine SCHEMBL8205468 0.91 GSR (0.43) GSRDPP7DPP4DPP8DPP9
D-Glutamate SCHEMBL29083846 0.90 GSR (0.33) GSRCYP1A2
Asparagine SCHEMBL28801799 0.90 NOS2 (0.33) DPP7NOS2NOS1NOS3CYP1A2
Asparagine SCHEMBL3864508 0.90 NOS2 (0.33) DPP7NOS2NOS1NOS3CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114853848-B Polypeptide compound and application thereof in preparation of medicines for treating liver fibrosis diseases 陕西慧康生物科技有限责任公司 2023-10-24 — — CN disclosed
CN-114853848-A Polypeptide compound and application thereof in preparing medicament for treating hepatic fibrosis diseases 陕西慧康生物科技有限责任公司 2022-08-05 — — CN disclosed