Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | PGK2 | P07205 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.32 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6512580 | 0.78 | TSHR (0.52) | TSHRALDH1A1PTPN1CA1CA2 | |
| SCHEMBL5609995 | 0.77 | TSHR (0.58) | TSHRALDH1A1PTPN1CA1CA2 | |
| SCHEMBL11149724 | 0.74 | KCNN4 (0.48) | TSHRALDH1A1PTPN1CA1CA2 | |
| SCHEMBL160204 | 0.71 | TSHR (0.58) | TSHRALDH1A1PTPN1CA1CA2 | |
| SCHEMBL146900 | 0.71 | TSHR (0.58) | TSHRALDH1A1PTPN1CA1CA2 | |
| SCHEMBL951559 | 0.71 | TSHR (0.58) | TSHRALDH1A1PTPN1CA1CA2 | |
| SCHEMBL17288747 | 0.71 | TSHR (0.58) | TSHRALDH1A1PTPN1CA1CA2 | |
| SCHEMBL11546152 | 0.71 | TSHR (0.58) | TSHRALDH1A1PTPN1CA1CA2 | |
| SCHEMBL612731 | 0.71 | ALDH1A1 (0.58) | TSHRALDH1A1PTPN1CA1CA2 | |
| SCHEMBL8582066 | 0.71 | TSHR (0.58) | TSHRALDH1A1PTPN1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1026150-B1 | (2-oxy substituted)-phenylalkanamide derivative, hair growth promoter and external composition for skin using the same | SHISEIDO CO LTD (JP) | 2011-06-29 | — | — | EP | disclosed |
| EP-0903344-B1 | Quinazolin-4-one derivatives, their preparation and their use as hair growth promoters or in external compositions for skin | SHISEIDO CO LTD (JP) | 2011-01-26 | — | — | EP | disclosed |
| US-6573297-B2 | Applying an effective amount of (2-substituted oxyphenyl)alkanamide derivatives to the skin of a mammal for promoting hair growth | SHISEIDO CO., LTD. (JP) | 2003-06-03 | — | — | US | disclosed |
| EP-0911320-B1 | 1,2-Di-substituted benzenecarboxamide derivative, hair growth promoter and external composition for skin using the same | SHISEIDO CO LTD (JP) | 2002-07-24 | — | — | EP | disclosed |
| EP-0940390-B1 | [6-(Substituted-methyl)-3-cyclohexenyl]formamide derivative, hair growth promoter and external composition for skin | SHISEIDO CO LTD (JP) | 2002-07-17 | — | — | EP | disclosed |
| US-20020052498-A1 | (2-substituted oxyphenyl)alkanamide derivative, hair growth promoter and external composition for skin using the same | SHISEIDO CO., LTD. (JP) | 2002-05-02 | — | — | US | disclosed |
| EP-0933361-B1 | 1,2-Di-substituted piperidine derivatives as hair growth promoter | SHISEIDO CO LTD (JP) | 2002-03-27 | — | — | EP | disclosed |
| US-6339154-B1 | THERAPY OF HAIR LOSS IN MAMMALS AND, IN PARTICULAR, IN HUMAN | SHISEIDO CO, LTD. (JP) | 2002-01-15 | — | — | US | disclosed |
| US-6204264-B1 | Benzimidazole derivative, hair growth promoter and external composition for skin using the same | SHISEIDO CO., LTD. (JP) | 2001-03-20 | — | — | US | disclosed |
| US-6174885-B1 | IMPROVEMENT OR PREVENTION OF HAIR LOSS IN MAMMALS AND, IN PARTICULAR, IN HUMAN | SHISEIDO CO., LTD. (JP) | 2001-01-16 | — | — | US | disclosed |
| US-6114325-A | 1,2-di-substituted benzene-carboxamide derivative, hair growth promoter and external composition for skin using the same | SHISEIDO CO., LTD. (JP) | 2000-09-05 | — | — | US | disclosed |
| EP-1026150-A1 | (2-oxy substituted)-phenylalkanamide derivative, hair growth promoter and external composition for skin using the same | SHISEIDO COMPANY LIMITED (JP) | 2000-08-09 | — | — | EP | disclosed |
| US-6057337-A | USEFUL FOR CARE, IMPROVEMENT OR PREVENTION OF HAIR LOSS | SHISEIDO CO., LTD. (JP) | 2000-05-02 | — | — | US | disclosed |
| EP-0989123-A1 | Benzimidazole derivative, hair growth promoter and external composition for skin using the same | SHISEIDO COMPANY LIMITED (JP) | 2000-03-29 | — | — | EP | disclosed |
| US-5972929-A | Quinazolinone derivative, hair growth promoter and external composition for skin using the same | SHISEIDO CO., LTD. (JP) | 1999-10-26 | — | — | US | disclosed |
| EP-0940390-A1 | 6- (Substituted-methyl) -3- cyclohexenyl formamide derivative, hair growth promoter and external composition for skin | SHISEIDO COMPANY LIMITED (JP) | 1999-09-08 | — | — | EP | disclosed |
| EP-0933361-A1 | 1,2-Di-substituted piperidine derivatives as hair growth promoter | SHISEIDO COMPANY LIMITED (JP) | 1999-08-04 | — | — | EP | disclosed |
| EP-0911320-A2 | 1,2-Di-substituted benzenecarboxamide derivative, hair growth promoter and external composition for skin using the same | SHISEIDO COMPANY LIMITED (JP) | 1999-04-28 | — | — | EP | disclosed |
| EP-0903344-A1 | Quinazolin-4-one derivatives, their preparation and their use as hair growth promoters or in external compositions for skin | SHISEIDO COMPANY LIMITED (JP) | 1999-03-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052498-A1 | (2-substituted oxyphenyl)alkanamide derivative, hair growth promoter and external composition for skin using the same | NR2E1, NCOR2, DECR2 | TSHR 489/4885ALDH1A1 2015/4885PTPN1 2157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.