SCHEMBL11546152

SCHEMBL11546152

FC(F)(F)C(c1ccccc1)(C(F)(F)F)C(F)(F)F

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.58
ALDH1A1 P00352 2/20 0.58
PTPN1 P18031 1/20 0.44
KCNN4 O15554 3/20 0.43
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA5A P35218 1/20 0.42
CA9 Q16790 1/20 0.42
KIF11 P52732 1/20 0.42
MAPK1 P28482 2/20 0.39
PGK1 P00558 1/20 0.36
PGK2 P07205 1/20 0.36
NR1H2 P55055 1/20 0.35
NR1H3 Q13133 1/20 0.35
CYP1A2 P05177 1/20 0.35
TAAR1 Q96RJ0 1/20 0.35
ALOX15 P16050 1/20 0.35
CES1 P23141 1/20 0.35
TRPV6 Q9H1D0 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6512553 0.80 TSHR (0.50) TSHRALDH1A1PTPN1KCNN4CA1
SCHEMBL10890440 0.76 NR1H2 (0.54) TSHRALDH1A1PTPN1KCNN4CA1
SCHEMBL16586837 0.76 TSHR (0.46) TSHRALDH1A1PTPN1KCNN4CA1
SCHEMBL17288747 0.75 TSHR (0.58) TSHRALDH1A1PTPN1KCNN4CA1
SCHEMBL160204 0.75 TSHR (0.58) TSHRALDH1A1PTPN1KCNN4CA1
SCHEMBL8582066 0.75 TSHR (0.58) TSHRALDH1A1PTPN1KCNN4CA1
SCHEMBL146900 0.75 TSHR (0.58) TSHRALDH1A1PTPN1KCNN4CA1
SCHEMBL951559 0.75 TSHR (0.58) TSHRALDH1A1PTPN1KCNN4CA1
SCHEMBL612731 0.75 ALDH1A1 (0.58) TSHRALDH1A1PTPN1KCNN4CA1
SCHEMBL1483475 0.75 TSHR (0.44) TSHRALDH1A1PTPN1KCNN4CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12403159-B2 Therapeutic metal complexes and ligands and methods of making and using the same OREGON STATE UNIVERSITY (US) 2025-09-02 US claimed
US-11596651-B2 Therapeutic metal complexes and ligands and methods of making and using the same OREGON STATE UNIVERSITY (US) 2023-03-07 US claimed
US-12403159-B2 Therapeutic metal complexes and ligands and methods of making and using the same OREGON STATE UNIVERSITY (US) 2025-09-02 US disclosed
US-20230172977-A1 THERAPEUTIC METAL COMPLEXES AND LIGANDS AND METHODS OF MAKING AND USING THE SAME OREGON STATE UNIVERSITY (US) 2023-06-08 US disclosed
US-11596651-B2 Therapeutic metal complexes and ligands and methods of making and using the same OREGON STATE UNIVERSITY (US) 2023-03-07 US disclosed
US-4147884-A Liquid phase oxidation of unsaturated aldehydes to corresponding acids ATLANTIC RICHFIELD COMPANY (US) 1979-04-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230172977-A1 THERAPEUTIC METAL COMPLEXES AND LIGANDS AND METHODS OF MAKING AND USING THE SAME TUFM, SMN1; SMN2, MCU TSHR 3811/4885ALDH1A1 293/4885PTPN1 4078/4885
US-12403159-B2 Therapeutic metal complexes and ligands and methods of making and using the same TUFM, SMN1; SMN2, MCU TSHR 3811/4885ALDH1A1 293/4885PTPN1 4078/4885
US-11596651-B2 Therapeutic metal complexes and ligands and methods of making and using the same TUFM, SMN1; SMN2, MCU TSHR 3811/4885ALDH1A1 293/4885PTPN1 4078/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.