Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | PKM | P14618 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | METAP2 | P50579 | 4/20 | 0.42 |
| ▸ | CBFB | Q13951 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | METAP1 | P53582 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4313385 | 0.82 | NPC1 (0.45) | NPC1PKMRAB9AKDM4EMETAP2 | |
| SCHEMBL10146529 | 0.70 | MAPT (0.52) | NPC1KDM4ESMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL28996530 | 0.70 | POLB (0.55) | NPC1PKMRAB9AKDM4EMETAP2 | |
| SCHEMBL30428608 | 0.70 | POLB (0.55) | NPC1PKMRAB9AKDM4EMETAP2 | |
| SCHEMBL16503975 | 0.68 | SMN1; SMN2 (0.47) | NPC1PKMRAB9AKDM4ECBFB | |
| SCHEMBL28171197 | 0.68 | TYMS (0.38) | NPC1RAB9AKDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL13383928 | 0.68 | ALDH1A1 (0.48) | NPC1PKMRAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL27545882 | 0.68 | KDM4E (0.50) | NPC1PKMRAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL7910798 | 0.67 | KDM4E (0.46) | NPC1PKMRAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL8296009 | 0.66 | NOS2 (0.41) | NPC1RAB9AKDM4EGAAPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4956351-A | INCLUSION COMPLEXESOFVIRICIDES; RHINITIS; SUSTAINED RELEASE; NONIRRITATING TO MUCOUS MEMBRANE | JANSSEN PHARMACEUTICA N.V. FRAME-543 (BE) | 1990-09-11 | — | — | US | disclosed |
| EP-0300526-A2 | Antiviral pharmaceutical compositions containing cyclodextrins | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-25 | — | — | EP | disclosed |