Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8588672 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL30525932 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL7928154 | 0.82 | GABRA1 (0.32) | FAAHCA1CA2LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL1041401 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL7030004 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL30525926 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL937824 | 0.81 | GABRA1 (0.30) | GABRA1GABRB2 | |
| Hydrochloric Acid SCHEMBL30525908 | 0.81 | GABRA1 (0.30) | GABRA1GABRB2 | |
| Hydrochloric Acid SCHEMBL968897 | 0.79 | FAAH (0.31) | FAAHCA1CA2LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL3378755 | 0.79 | FAAH (0.31) | FAAHCA1CA2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397400-B1 | LATENT METALLOCENE CATALYST SYSTEMS FOR OLEFIN POLYMERIZATION | INEOS USA LLC (US) | 2011-07-13 | — | — | EP | disclosed |
| EP-2275453-A1 | Latent metallocene catalyst systems for olefin polymerization | Ineos USA LLC (US) | 2011-01-19 | — | — | EP | disclosed |
| EP-1373325-B1 | LATENT METALLOCENE CATALYST SYSTEMS FOR OLEFIN POLYMERIZATION | INEOS USA LLC (US) | 2008-03-19 | — | — | EP | disclosed |
| US-7041757-B2 | Latent metallocene catalyst systems for olefin polymerization | INNOVENE USA LLC (US) | 2006-05-09 | — | — | US | disclosed |
| US-6998449-B2 | Latent metallocene catalyst systems for olefin polymerization | BP CORPORATION NORTH AMERICA (US) | 2006-02-14 | — | — | US | disclosed |
| US-20050026773-A1 | Latent metallocene catalyst systems for olefin polymerization | HALL RICHARD A (US) | 2005-02-03 | — | — | US | disclosed |
| US-6803339-B2 | TEMPORARILY AND REVERSIBLY PASSIVATING BY CONTACTING WITH AN UNSATURATED HYDROCARBON, SUCH AS C4-C14 ALKYNES, C4-C14 ALLENES AND CYCLOALKENES. | BP CORPORATION NORTH AMERICA INC. | 2004-10-12 | — | — | US | disclosed |
| EP-1397400-A1 | LATENT METALLOCENE CATALYST SYSTEMS FOR OLEFIN POLYMERIZATION | BP Corporation North America Inc. (US) | 2004-03-17 | — | — | EP | disclosed |
| EP-1373325-A2 | LATENT METALLOCENE CATALYST SYSTEMS FOR OLEFIN POLYMERIZATION | BP Corporation North America Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| US-6613845-B1 | Propylene/ethylene-α-olefin block copolymer and process for producing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2003-09-02 | — | — | US | disclosed |
| US-5990242-A | Propylene/ethylene-α-olefin block copolymer and process for processing the same | SUMITOMO CHEMICAL CO., LTD. (JP) | 1999-11-23 | — | — | US | disclosed |
| EP-0653433-B1 | Novel transition metal compound, olefin polymerization catalyst component comprising the transition metal compound, olefin polymerization catalyst comprising the olefin polymerization catalyst component, and process for olefin polymerization | MITSUI CHEMICALS INC (JP) | 1999-01-13 | — | — | EP | disclosed |
| US-5840644-A | OLEFIN POLYMERIZATION CATALYSTS | TARGOR GMBH (DE) | 1998-11-24 | — | — | US | disclosed |
| US-5786432-A | POLYMERIZING OR COPOLYMERIZING OLEFIN IN PRESENCE OF TRANSITION METAL METALLOCENE CATALYST AND COCATALYST | TARGOR GMBH (DE) | 1998-07-28 | — | — | US | disclosed |
| US-5776851-A | COORDINATION POLYMERIZATION CATALYST | TARGOR GMBH (DE) | 1998-07-07 | — | — | US | disclosed |
| EP-0822938-A1 | ENHANCED SYNTHESIS OF RACEMIC METALLOCENES | ALBEMARLE CORPORATION (US) | 1998-02-11 | — | — | EP | disclosed |
| US-5693730-A | METALLOCENES HAVING MORE THAN ONE CENTRAL ATOM AND A SPECIAL BRIDGE STRUCTURE FOR PREPARING ISOTACTIC, HIGH-MOLECULAR-WEIGHT POLYMERS HAVING GOOD GRAIN MORPHOLOGY; PROPYLENE HOMO- AND COPOLYMERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-02 | — | — | US | disclosed |
| US-5585508-A | POLYMERIZATION CATALYST FOR POLYOLEFINS | HOECHST AG (DE) | 1996-12-17 | — | — | US | disclosed |
| WO-1996034002-A1 | ENHANCED SYNTHESIS OF RACEMIC METALLOCENES | ALBEMARLE CORPORATION (US) | 1996-10-31 | — | — | WO | disclosed |
| EP-0653433-A1 | Novel transition metal compound, olefin polymerization catalyst component comprising the transition metal compound, olefin polymerization catalyst comprising the olefin polymerization catalyst component, and process for olefin polymerization | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |