Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.41 |
| ▸ | MMP2 | P08253 | 9/20 | 0.38 |
| ▸ | MMP1 | P03956 | 4/20 | 0.38 |
| ▸ | MMP3 | P08254 | 4/20 | 0.38 |
| ▸ | CCKBR | P32239 | 2/20 | 0.37 |
| ▸ | CCKAR | P32238 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | CPA1 | P15085 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10433962 | 0.77 | REN (0.53) | REN | |
| SCHEMBL7300127 | 0.73 | ACE (0.57) | RENCCKBRCCKARPTPN1ACE | |
| SCHEMBL10522069 | 0.73 | ACE (0.57) | RENCCKBRCCKARPTPN1ACE | |
| SCHEMBL23598225 | 0.73 | ACE (0.57) | RENCCKBRCCKARPTPN1ACE | |
| SCHEMBL28571315 | 0.73 | CTSS (0.57) | RENCCKBRCCKARPTPN1ACE | |
| SCHEMBL30882337 | 0.73 | CTSS (0.57) | RENCCKBRCCKARPTPN1ACE | |
| SCHEMBL28571321 | 0.73 | CTSS (0.57) | RENCCKBRCCKARPTPN1ACE | |
| SCHEMBL10522277 | 0.70 | REN (0.49) | RENKLK5 | |
| SCHEMBL30152073 | 0.70 | GNPAT (0.52) | MMP2MMP1MMP3MMEACE | |
| Dl-Phenylalanine SCHEMBL28124565 | 0.69 | ACE (0.53) | RENCCKBRCCKARPTPN1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369141-A1 | Aspartic protease inhibitors for the treatment of diseases caused by retroviruses | MERCK PATENT GmbH (DE) | 1990-05-23 | — | — | EP | disclosed |