Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9671299 | 0.86 | ALDH1A1 (0.41) | GAANPSR1ALDH1A1CYP1A2TDP1 | |
| SCHEMBL1444267 | 0.83 | GAA (0.61) | GAANPSR1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL10434676 | 0.83 | GAA (0.50) | GAANPSR1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL23295 | 0.79 | PTGS2 (0.53) | GAAALDH1A1CYP2C19SMN1; SMN2LMNA | |
| SCHEMBL10435028 | 0.79 | GAA (0.39) | GAANPSR1ALDH1A1TSHRCYP1A2 | |
| SCHEMBL3169853 | 0.78 | ALOX15 (0.42) | GAAALDH1A1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL3164789 | 0.77 | ALDH1A1 (0.44) | GAAALDH1A1TSHRSMN1; SMN2THRB | |
| SCHEMBL10434758 | 0.76 | MAPT (0.46) | GAANPSR1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL10434626 | 0.76 | ALDH1A1 (0.42) | GAAALDH1A1TSHRTDP1THRB | |
| SCHEMBL7534787 | 0.75 | TSHR (0.39) | GAANPSR1TSHRCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0374756-A2 | Nitrogen-containing cyclic compounds | MERCK PATENT GmbH (DE) | 1990-06-27 | — | — | EP | disclosed |