Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.59 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.59 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | PLG | P00747 | 2/20 | 0.51 |
| ▸ | KLK1 | P06870 | 2/20 | 0.51 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 5/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL104335 | 0.85 | NPC1 (0.50) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL104343 | 0.84 | HRH3 (0.52) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL104356 | 0.84 | HPGD (0.62) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL104388 | 0.81 | ALDH1A1 (0.56) | TAS1R3TAS1R1TAS1R2RAB9AHPGD | |
| SCHEMBL4066954 | 0.80 | TAS1R3 (0.88) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL13253682 | 0.79 | PLG (0.57) | PLGKLK1KLK6HPGDKDM4E | |
| SCHEMBL4219383 | 0.76 | HPGD (0.69) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL4218063 | 0.76 | RAB9A (0.63) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL105169 | 0.76 | RAB9A (0.57) | NPC1RAB9AHPGDLMNAMAPT | |
| SCHEMBL14924112 | 0.75 | KMT2A (0.46) | NPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059162-A1 | FUSED IMIDAZOLE DERIVATIVE HAVING TTK INHIBITORY ACTION | NR0B1, GRK7, NR5A2 | TAS1R3 1218/4885TAS1R1 1469/4885TAS1R2 1346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.