SCHEMBL10436627

SCHEMBL10436627

Cc1ccc(C2(c3c(C)[nH]c4ccccc34)OC(=O)c3ccccc32)c(N)c1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.41
LMNA P02545 6/20 0.41
NPSR1 Q6W5P4 4/20 0.41
POLB P06746 3/20 0.41
ALOX12 P18054 2/20 0.41
GPR55 Q9Y2T6 1/20 0.41
CYP3A4 P08684 3/20 0.38
CYP2C19 P33261 3/20 0.38
CYP1A2 P05177 2/20 0.38
CYP2C9 P11712 2/20 0.38
ALDH1A1 P00352 4/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
TDP1 Q9NUW8 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
CFTR P13569 1/20 0.37
GOPC Q9HD26 1/20 0.37
TP53 P04637 3/20 0.37
THRB P10828 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6381987 0.89 NPSR1 (0.39) MAPTLMNANPSR1POLBALOX12
SCHEMBL3228674 0.85 LMNA (0.50) MAPTLMNANPSR1POLBALOX12
SCHEMBL50862 0.82 LMNA (0.57) MAPTLMNANPSR1POLBALOX12
SCHEMBL28348436 0.80 CFTR (0.57) MAPTLMNANPSR1POLBALOX12
SCHEMBL5147481 0.79 MAPT (0.47) MAPTLMNANPSR1POLBALOX12
SCHEMBL10528872 0.79 LMNA (0.42) MAPTLMNANPSR1POLBALOX12
SCHEMBL31715256 0.79 LMNA (0.42) MAPTLMNANPSR1POLBALOX12
SCHEMBL9618089 0.77 LMNA (0.40) MAPTLMNANPSR1POLBALOX12
SCHEMBL4578036 0.76 MAPT (0.45) MAPTLMNANPSR1POLBALOX12
SCHEMBL11244641 0.76 ALDH1A1 (0.45) MAPTLMNANPSR1POLBALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0363961-A2 Thermosensitive recording material MITSUBISHI PAPER MILLS, LTD. (JP) 1990-04-18 EP disclosed
EP-0361501-A2 Thermosensitive recording materials MITSUBISHI PAPER MILLS, LTD. (JP) 1990-04-04 EP disclosed
EP-0361500-A2 Thermosensitive recording materials MITSUBISHI PAPER MILLS, LTD. (JP) 1990-04-04 EP disclosed
EP-0314980-A2 Heat-sensitive recording material MITSUBISHI PAPER MILLS, LTD. (JP) 1989-05-10 EP disclosed