Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | OGT | O15294 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10338403 | 0.77 | PDE3B (0.61) | SYKPDE3BPDE3ANOS1P2RX3 | |
| SCHEMBL10359665 | 0.74 | SYK (0.55) | SYKPDE3BPDE3ANOS1JAK1 | |
| SCHEMBL10437460 | 0.73 | SYK (0.49) | SYKPDE3BPDE3ANOS1P2RX3 | |
| SCHEMBL10437477 | 0.72 | SYK (0.48) | SYKPDE3BPDE3ANOS1P2RX3 | |
| SCHEMBL8311380 | 0.71 | NOS1 (0.61) | SYKPDE3BPDE3ANOS1CREBBP | |
| SCHEMBL21925302 | 0.71 | SYK (0.56) | SYKPDE3BPDE3ANOS1P2RX3 | |
| SCHEMBL10437432 | 0.70 | SYK (0.49) | SYKPDE3BPDE3ANOS1P2RX3 | |
| SCHEMBL340018 | 0.70 | JAK1 (0.61) | SYKJAK1JAK3CYP1A2 | |
| SCHEMBL16881704 | 0.70 | POLA1 (0.44) | LMNA | |
| SCHEMBL5318423 | 0.69 | VCP (0.56) | SYKPDE3BPDE3ANOS1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0360566-A2 | Lipoxygenase/cyclooxygenase inhibiting benzoxazolones | PFIZER INC. (US) | 1990-03-28 | — | — | EP | disclosed |