Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 9/20 | 0.45 |
| ▸ | MMP3 | P08254 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4840536 | 1.00 | MMP8 (0.45) | MMP8MMP3ALDH1A1NPSR1RAB9A | |
| SCHEMBL4840519 | 0.99 | MMP8 (0.44) | MMP8MMP3ALDH1A1NPSR1RAB9A | |
| SCHEMBL4840527 | 0.93 | MMP8 (0.44) | MMP8MMP3ALDH1A1NPSR1RAB9A | |
| SCHEMBL4838417 | 0.92 | MMP8 (0.44) | MMP8MMP3ALDH1A1NPSR1RAB9A | |
| SCHEMBL4833757 | 0.92 | CA12 (0.42) | MMP8MMP3ALDH1A1NPSR1RAB9A | |
| SCHEMBL4833189 | 0.90 | MMP8 (0.49) | MMP8MMP3ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL4842689 | 0.90 | MMP8 (0.39) | MMP8MMP3ALDH1A1NPSR1PTGER3 | |
| SCHEMBL4845030 | 0.90 | ALDH1A1 (0.40) | MMP8MMP3ALDH1A1NPSR1RAB9A | |
| SCHEMBL4844870 | 0.90 | MAPT (0.42) | MMP8MMP3ALDH1A1NPSR1MMP1 | |
| SCHEMBL4833917 | 0.89 | MMP8 (0.43) | MMP8MMP3ALDH1A1NPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268270-A2 | IMPROVED FORMULATIONS FOR POORLY PERMEABLE ACTIVE PHARMACEUTICAL INGREDIENTS | Abbott Products GmbH (DE) | 2011-01-05 | — | — | EP | claimed |
| WO-2009130204-A2 | IMPROVED FORMULATIONS FOR POORLY PERMEABLE ACTIVE PHARMACEUTICAL INGREDIENTS | SOLVAY PHARMACEUTICALS GMBH (DE) | 2009-10-29 | — | — | WO | claimed |
| US-20090263479-A1 | FORMULATIONS FOR POORLY PERMEABLE ACTIVE PHARMACEUTICAL INGREDIENTS | SOLVAY PHAMACEUTICALS GMBH | 2009-10-22 | — | — | US | claimed |
| US-20090263479-A1 | FORMULATIONS FOR POORLY PERMEABLE ACTIVE PHARMACEUTICAL INGREDIENTS | SOLVAY PHAMACEUTICALS GMBH | 2009-10-22 | — | — | US | disclosed |
| US-7465811-B2 | Indoline compounds | LABORATOIRES FOURNIER S.A. (FR) | 2008-12-16 | — | — | US | disclosed |
| US-20080119465-A1 | Novel Indoline Compounds | LABORATORIES FOURNIER S.A. (FR) | 2008-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119465-A1 | Novel Indoline Compounds | GPR119, INSR, IRS1 | MMP8 3968/4885MMP3 3739/4885ALDH1A1 1819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.