SCHEMBL10440183

SCHEMBL10440183

C(=Cc1cc(Nc2ccccc2)c(Nc2ccccc2)c(N2CCOCC2)c1N1CCOCC1)c1ccccc1.[NaH]

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKDC P78527 2/20 0.41
ALDH1A1 P00352 4/20 0.40
ALOX15 P16050 1/20 0.40
TSHR P16473 1/20 0.40
LMNA P02545 2/20 0.40
HTT P42858 2/20 0.40
KDM1A O60341 1/20 0.39
IGF1R P08069 1/20 0.38
MAPT P10636 3/20 0.38
KDM4E B2RXH2 2/20 0.38
HPGD P15428 2/20 0.38
RAB9A P51151 2/20 0.38
NPC1 O15118 1/20 0.38
GAA P10253 1/20 0.38
ALOX12 P18054 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MAOB P27338 1/20 0.37
PLK4 O00444 1/20 0.37
PIK3CA P42336 2/20 0.36
PIK3CD O00329 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10486391 0.99 PRKDC (0.42) PRKDCALDH1A1ALOX15TSHRLMNA
SCHEMBL10440180 0.71 LMNA (0.46) PRKDCALDH1A1LMNAHTTKDM1A
SCHEMBL18796549 0.68 LMNA (0.65) LMNAHTTMAPTGAASMN1; SMN2
SCHEMBL9218385 0.68 PRKDC (0.51) PRKDCALDH1A1ALOX15TSHRLMNA
SCHEMBL4623931 0.68 LMNA (0.60) LMNAHTTMAPTGAASMN1; SMN2
SCHEMBL26115603 0.67 LMNA (0.50) ALDH1A1LMNAHTTKDM1AMAPT
SCHEMBL3880764 0.66 LMNA (0.75) LMNAHTTMAPTGAASMN1; SMN2
SCHEMBL8925967 0.66 LMNA (0.75) LMNAHTTMAPTGAASMN1; SMN2
SCHEMBL29013980 0.66 MAPT (0.65) PRKDCALDH1A1ALOX15TSHRLMNA
SCHEMBL2604938 0.66 MAPT (0.65) PRKDCALDH1A1ALOX15TSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0404377-A1 Water soluble copolymers of maleic anhydride AUSIDET S.R.L. (IT) 1990-12-27 EP disclosed