Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 2/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 16/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 14/20 | 0.36 |
| ▸ | PER2 | O15055 | 1/20 | 0.34 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.34 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1043474 | 0.79 | OPRL1 (0.50) | CARM1 | |
| SCHEMBL1044566 | 0.74 | PRMT5 (0.44) | CARM1PRMT5WDR77ALDH1A1 | |
| SCHEMBL1045644 | 0.71 | CARM1 (0.44) | CARM1PRMT5WDR77 | |
| SCHEMBL23166533 | 0.64 | SLC18A3 (0.40) | ALDH1A1 | |
| SCHEMBL29563547 | 0.64 | CARM1 (0.61) | CARM1PRMT5WDR77ALDH1A1 | |
| SCHEMBL11245575 | 0.64 | GBA1 (0.45) | CARM1ALDH1A1 | |
| SCHEMBL5402661 | 0.63 | OPRM1 (0.62) | CARM1 | |
| Hydrochloric Acid SCHEMBL11248658 | 0.62 | GBA1 (0.44) | CARM1ALDH1A1 | |
| SCHEMBL20741224 | 0.62 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL1041403 | 0.61 | LMNA (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271613-B1 | HYDROXYMETHYLCYCLOHEXYLAMINES | GRUENENTHAL GMBH (DE) | 2014-06-18 | — | — | EP | disclosed |
| US-8288406-B2 | Hydroxymethylcyclohexylamines | GRUENENTHAL GMBH (DE) | 2012-10-16 | — | — | US | disclosed |
| US-20110059999-A1 | Hydroxymethylcyclohexylamines | Grünenthal GmbH (DE) | 2011-03-10 | — | — | US | disclosed |
| EP-2271613-A1 | HYDROXYMETHYLCYCLOHEXYL AMINES | Grünenthal GmbH (DE) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009118171-A1 | HYDROXYMETHYLCYCLOHEXYL AMINES | Grünenthal GmbH (DE) | 2009-10-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059999-A1 | Hydroxymethylcyclohexylamines | OPRL1, OPRM1, OPRD1 | CARM1 521/4885PRMT5 673/4885WDR77 628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.