Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 14/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | PGR | P06401 | 2/20 | 0.58 |
| ▸ | AR | P10275 | 2/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6699256 | 0.82 | CYP19A1 (1.00) | CYP19A1PGRARCHRM1 | |
| SCHEMBL7592337 | 0.79 | CYP19A1 (0.70) | CYP19A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL144436 | 0.78 | LMNA (0.72) | CYP19A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL1650395 | 0.78 | LMNA (0.72) | CYP19A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL8859777 | 0.78 | LMNA (0.67) | CYP19A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL10868391 | 0.78 | LMNA (0.72) | CYP19A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL10444545 | 0.77 | LMNA (0.63) | CYP19A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL369752 | 0.76 | CYP3A4 (0.66) | CYP19A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL6577137 | 0.76 | PGR (0.69) | CYP19A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL18402585 | 0.76 | CYP3A4 (0.66) | CYP19A1LMNAMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4416821-A | Process for preparing 16-methylene steroids | THE UPJOHN COMPANY (US) | 1983-11-22 | — | — | US | claimed |
| EP-0402963-A2 | 17-Alpha ethynyl steroids | THE UPJOHN COMPANY (US) | 1990-12-19 | — | — | EP | disclosed |
| US-4614621-A | Ethynylation of 16-methylene-17-keto steroids | THE UPJOHN COMPANY (US) | 1986-09-30 | — | — | US | disclosed |
| EP-0179496-A1 | 16-Sulfinylmethyl-steroids, their preparation and use | THE UPJOHN COMPANY (US) | 1986-04-30 | — | — | EP | disclosed |
| US-4567001-A | 16-Methylene-17α-hydroxy-progesterones | THE UPJOHN COMPANY (US) | 1986-01-28 | — | — | US | disclosed |
| EP-0148616-A2 | Stabilised monolithium acetylide and the ethynylation of steroids | THE UPJOHN COMPANY (US) | 1985-07-17 | — | — | EP | disclosed |
| US-4526720-A | Process to prepare stabilized monolithium acetylide | THE UPJOHN COMPANY (US) | 1985-07-02 | — | — | US | disclosed |
| EP-0104054-A2 | 16-methylene-steroids and their preparation | THE UPJOHN COMPANY (US) | 1984-03-28 | — | — | EP | disclosed |