Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPOR | P19235 | 5/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9491983 | 0.92 | EPOR (0.52) | EPORALOX5MAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9493233 | 0.92 | EPOR (0.52) | EPORALOX5MAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9492580 | 0.88 | EPOR (0.46) | EPORALOX5ALDH1A1HPGDPTGS1 | |
| Hydrochloric Acid SCHEMBL9493052 | 0.88 | EPOR (0.46) | EPORALOX5ALDH1A1HPGDPTGS1 | |
| Hydrochloric Acid SCHEMBL9493796 | 0.79 | TTR (0.35) | EPORALOX5MAPTALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL9493793 | 0.79 | TTR (0.35) | EPORALOX5MAPTALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL2452749 | 0.74 | HTR2A (0.50) | HIF1AGRIK1GRIK2 | |
| Hydrochloric Acid SCHEMBL2452746 | 0.74 | HTR2A (0.50) | HIF1AGRIK1GRIK2 | |
| SCHEMBL13073712 | 0.72 | NFE2L2 (0.57) | ALOX5MAPTMEN1ALDH1A1TP53 | |
| Water SCHEMBL8528185 | 0.71 | HTR2A (0.50) | HIF1AGRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0390228-A2 | Chemical intermediates | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-10-03 | — | — | EP | disclosed |
| EP-0240121-A2 | Diphenyl ether derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-10-07 | — | — | EP | disclosed |