Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.34 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.34 |
| ▸ | EPOR | P19235 | 3/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9493796 | 1.00 | TTR (0.35) | TTRGRIK1GRIK2GRIK3CHRNA7 | |
| SCHEMBL29110079 | 0.80 | EPOR (0.40) | TTREPORHRH1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL9491983 | 0.80 | EPOR (0.52) | GRIK1GRIK2EPORMAPTALOX5 | |
| SCHEMBL9496444 | 0.80 | TTR (0.39) | TTREPORHRH1ALDH1A1MAPT | |
| SCHEMBL9496431 | 0.80 | TTR (0.39) | TTREPORHRH1ALDH1A1MAPT | |
| SCHEMBL9804304 | 0.80 | ALDH1A1 (0.42) | TTREPORHRH1ALDH1A1MAPT | |
| SCHEMBL29110082 | 0.80 | EPOR (0.40) | TTREPORHRH1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL9493233 | 0.80 | EPOR (0.52) | GRIK1GRIK2EPORMAPTALOX5 | |
| Hydrochloric Acid SCHEMBL10446299 | 0.79 | EPOR (0.46) | GRIK1GRIK2EPORALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL9492580 | 0.76 | EPOR (0.46) | GRIK1GRIK2EPORALDH1A1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279531-B1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF INSECTICIDALLY ACTIVE COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-03-10 | — | — | EP | claimed |
| EP-0279531-A2 | Process and intermediates for the preparation of insecticidally active compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-08-24 | — | — | EP | claimed |
| EP-0279531-B1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF INSECTICIDALLY ACTIVE COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-03-10 | — | — | EP | disclosed |
| US-5081273-A | PROCESS FOR THE PREPARATION OF INSECTICIDALLY ACTIVE DIPHENYL ETHER COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-01-14 | — | — | US | disclosed |
| US-4942264-A | WITTIG REACTION FOLLOWED BY REDUCTION | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-07-17 | — | — | US | disclosed |
| EP-0279531-A2 | Process and intermediates for the preparation of insecticidally active compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-08-24 | — | — | EP | disclosed |