Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | TSHR | P16473 | 9/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8455166 | 0.85 | ALDH1A1 (0.50) | ALDH1A1TSHRHPGDHSD17B10CA2 | |
| Propene SCHEMBL29050248 | 0.85 | — | — | |
| Propene SCHEMBL27503065 | 0.85 | — | — | |
| Acrylic Acid SCHEMBL26134427 | 0.83 | LMNA (0.56) | ALDH1A1TSHRLMNAHPGDTP53 | |
| Bicarbonate SCHEMBL28086039 | 0.82 | ALDH1A1 (0.48) | ALDH1A1TSHRHPGDHSD17B10CA2 | |
| Bicarbonate SCHEMBL28800487 | 0.82 | LMNA (0.41) | ALDH1A1TSHRLMNACA2 | |
| Propene SCHEMBL219263 | 0.80 | ALDH1A1 (0.46) | ALDH1A1TSHRLMNAHPGDTP53 | |
| Propene SCHEMBL487681 | 0.80 | ALDH1A1 (0.46) | ALDH1A1TSHRLMNAHPGDTP53 | |
| 2-Methoxyethanol SCHEMBL5954194 | 0.80 | TSHR (0.41) | ALDH1A1TSHR | |
| Propene SCHEMBL15666 | 0.80 | ALDH1A1 (0.46) | ALDH1A1TSHRLMNAHPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397222-A2 | Microporous films | SCIMAT LIMITED (GB) | 1990-11-14 | — | — | EP | disclosed |