Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.41 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRE | P78334 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542263 | 0.82 | ACHE (0.49) | ACHEBACE1CA2MAPK1HCAR2 | |
| SCHEMBL21694699 | 0.78 | ACHE (0.51) | ACHEBACE1CA2MAPK1HCAR2 | |
| SCHEMBL21694697 | 0.78 | ACHE (0.51) | ACHEBACE1CA2MAPK1HCAR2 | |
| SCHEMBL8965248 | 0.77 | ACHE (0.55) | ACHEBACE1CA2MAPK1HCAR2 | |
| SCHEMBL8965243 | 0.77 | ACHE (0.55) | ACHEBACE1CA2MAPK1HCAR2 | |
| SCHEMBL4834330 | 0.77 | GABRP (0.48) | ACHEBACE1HCAR2GABRPGABRD | |
| SCHEMBL9579602 | 0.76 | ACHE (0.46) | ACHEBACE1CA2MAPK1HCAR2 | |
| SCHEMBL4826151 | 0.76 | ACHE (0.53) | ACHEBACE1CA2MAPK1HCAR2 | |
| SCHEMBL4826149 | 0.76 | ACHE (0.53) | ACHEBACE1CA2MAPK1HCAR2 | |
| SCHEMBL8090945 | 0.73 | ACHE (0.76) | ACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0185380-B1 | THIOL BASED COLLAGENASE INHIBITORS | G.D. Searle & Co. (US) | 1990-04-11 | — | — | EP | disclosed |
| US-4681966-A | ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1987-07-21 | — | — | US | disclosed |
| EP-0185380-A2 | Thiol based collagenase inhibitors | G.D. Searle & Co. (US) | 1986-06-25 | — | — | EP | disclosed |
| US-4595700-A | Thiol based collagenase inhibitors | G. D. SEARLE & CO. (US) | 1986-06-17 | — | — | US | disclosed |