Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | HTT | P42858 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416728 | 0.86 | HTT (0.76) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7877042 | 0.84 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL4182162 | 0.83 | KMT2A (0.77) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL5188475 | 0.82 | ALDH1A1 (0.81) | ALDH1A1KMT2ASMN1; SMN2POLBMEN1 | |
| SCHEMBL10451944 | 0.81 | AKR1C3 (0.61) | ALDH1A1HTTSMN1; SMN2POLB | |
| SCHEMBL7877032 | 0.80 | ALDH1A1 (0.60) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL10462165 | 0.79 | TBXA2R (0.63) | ALDH1A1HTTKMT2ALMNAMAPK1 | |
| SCHEMBL7420609 | 0.79 | HTT (0.78) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL5169194 | 0.77 | KMT2A (0.69) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL5524577 | 0.77 | ALDH1A1 (0.79) | ALDH1A1HTTKMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221344-B1 | SULPHONYL-PHENYL ALKYL AMINES, PROCESS FOR THEIR PREPARATION AND MEDICINES | Roche Diagnostics GmbH (DE) | 1990-05-23 | — | — | EP | disclosed |