Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10453025 | 0.86 | PDE4A (0.66) | HTTALDH1A1POLBNPSR1TSHR | |
| SCHEMBL5960056 | 0.86 | HTT (1.00) | HTTALDH1A1POLBSMN1; SMN2SFRP1 | |
| SCHEMBL7415584 | 0.86 | SMN1; SMN2 (0.78) | HTTALDH1A1POLBNPSR1TSHR | |
| SCHEMBL4182162 | 0.85 | KMT2A (0.77) | HTTALDH1A1POLBNPSR1TSHR | |
| SCHEMBL10462165 | 0.84 | TBXA2R (0.63) | HTTALDH1A1POLBSMN1; SMN2KMT2A | |
| SCHEMBL7877042 | 0.83 | PDE4A (0.65) | HTTALDH1A1POLBNPSR1SMN1; SMN2 | |
| SCHEMBL9895995 | 0.83 | HTT (0.75) | HTTALDH1A1POLBNPSR1SMN1; SMN2 | |
| SCHEMBL4617736 | 0.83 | ALDH1A1 (0.72) | HTTALDH1A1POLBSMN1; SMN2TP53 | |
| SCHEMBL6104071 | 0.82 | HTT (0.81) | HTTALDH1A1POLBNPSR1SMN1; SMN2 | |
| SCHEMBL7877032 | 0.82 | ALDH1A1 (0.60) | HTTALDH1A1POLBSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |