Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | ITGAV | P06756 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10452827 | 0.82 | ALDH1A1 (0.54) | ALDH1A1MAPT | |
| SCHEMBL10452731 | 0.82 | NSD2 (0.48) | ALDH1A1SMN1; SMN2CASP1KDM4EMAPT | |
| SCHEMBL6568071 | 0.80 | F10 (0.64) | ALDH1A1SMN1; SMN2F10HTTPLA2G4A | |
| SCHEMBL10452821 | 0.78 | TAAR1 (0.57) | ALDH1A1SGMS1POLBMAPT | |
| SCHEMBL10461810 | 0.77 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2F10ITGAVHTT | |
| SCHEMBL10451941 | 0.76 | RAB9A (0.55) | ALDH1A1SGMS1KDM4EMAPT | |
| SCHEMBL10453042 | 0.76 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2POLBMAPT | |
| SCHEMBL10452830 | 0.75 | TBXA2R (0.61) | ALDH1A1SGMS1TP53MAPT | |
| SCHEMBL10451939 | 0.74 | AKR1C3 (0.55) | ALDH1A1F10TP53MAPT | |
| SCHEMBL10463338 | 0.73 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2F10HTTPLA2G4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221344-B1 | SULPHONYL-PHENYL ALKYL AMINES, PROCESS FOR THEIR PREPARATION AND MEDICINES | Roche Diagnostics GmbH (DE) | 1990-05-23 | — | — | EP | disclosed |
| EP-0221344-A1 | Sulphonyl-phenyl alkyl amines, process for their preparation and medicines | Roche Diagnostics GmbH (DE) | 1987-05-13 | — | — | EP | disclosed |