Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 2/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 4/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10454117 | 0.99 | HCRTR1 (0.37) | HCRTR1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL10454116 | 0.99 | HCRTR1 (0.37) | HCRTR1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL10453998 | 0.88 | HCRTR1 (0.33) | HCRTR1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL11614996 | 0.88 | CASP3 (0.40) | HCRTR1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL10454088 | 0.84 | HCRTR1 (0.32) | HCRTR1RAB9ACASP3SENP7SENP6 | |
| SCHEMBL10454186 | 0.82 | RAB9A (0.54) | HCRTR1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL10454114 | 0.82 | MAOA (0.51) | RAB9AMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL10452882 | 0.82 | KDM4E (0.57) | RAB9AMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL10453999 | 0.82 | HTR1A (0.39) | HCRTR1RAB9AALDH1A1GLANPC1 | |
| SCHEMBL10453856 | 0.82 | HCRTR1 (0.51) | HCRTR1RAB9AMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4902701-A | Tetrazolyl substituted tricyclic compounds and pharmacological compositions thereof | BURROUGHS WELCOME CO. (US) | 1990-02-20 | — | — | US | disclosed |
| EP-0093381-B1 | TRICYCLIC COMPOUNDS, PREPARATION, USE AND INTERMEDIATES | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-07-23 | — | — | EP | disclosed |
| EP-0093381-A1 | Tricyclic compounds, preparation, use and intermediates | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-11-09 | — | — | EP | disclosed |