Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 2/20 | 0.40 |
| ▸ | LAP3 | P28838 | 2/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10458230 | 0.80 | ELANE (0.47) | MEN1LMNARECQLKMT2ANPSR1 | |
| SCHEMBL11388122 | 0.77 | MEN1 (0.43) | MEN1LMNARECQLKMT2ANPSR1 | |
| SCHEMBL10400079 | 0.76 | ELANE (0.56) | ANPEPLAP3KLK1PLAUELANE | |
| SCHEMBL11388126 | 0.75 | NPSR1 (0.42) | MEN1LMNARECQLKMT2ANPSR1 | |
| SCHEMBL10458711 | 0.74 | ANPEP (0.41) | SRCANPEPLAP3KLK1PLAU | |
| SCHEMBL5147638 | 0.73 | NPSR1 (0.54) | MEN1LMNARECQLKMT2ANPSR1 | |
| Bromide SCHEMBL5146297 | 0.72 | NPSR1 (0.53) | MEN1LMNARECQLKMT2ANPSR1 | |
| SCHEMBL8766747 | 0.72 | KIF11 (0.51) | LMNAKMT2ANPSR1KIF11ESR1 | |
| SCHEMBL26003353 | 0.70 | NPSR1 (0.54) | MEN1LMNARECQLKMT2ANPSR1 | |
| SCHEMBL131325 | 0.70 | NPSR1 (0.50) | MEN1LMNARECQLKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4957912-A | ANTIBIOTICS | MERCK & CO., INC. (US) | 1990-09-18 | — | — | US | disclosed |
| US-4226866-A | BACTERICIDES, ACYLATION | MERCK & CO., INC. (US) | 1980-10-07 | — | — | US | disclosed |
| US-4086423-A | CEPHALOSPORINS, CYCLOADDITION OF GLYCINE DERIVATIVE TO THIAZINE COMPOUND | MERCK & CO., INC. (US) | 1978-04-25 | — | — | US | disclosed |
| US-3962224-A | CHEMICAL INTERMEDIATES FOR ANTIBIOTICS | MERCK & CO., INC. (US) | 1976-06-08 | — | — | US | disclosed |