Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10467190 | 0.79 | RAB9A (0.42) | ALDH1A1L3MBTL1NPC1MEN1KMT2A | |
| SCHEMBL10465699 | 0.78 | HSP90AA1 (0.41) | ALOX15ALDH1A1MAPK1HSP90AA1TLR9 | |
| SCHEMBL11796056 | 0.74 | ALOX15 (0.46) | ALOX15ALDH1A1MAPK1HSP90AA1TLR9 | |
| SCHEMBL31550899 | 0.74 | ALOX15 (0.46) | ALOX15ALDH1A1MAPK1HSP90AA1TLR9 | |
| SCHEMBL15423725 | 0.74 | ALOX15 (0.46) | ALOX15ALDH1A1MAPK1HSP90AA1TLR9 | |
| SCHEMBL18697953 | 0.72 | KMT2A (0.37) | MAPK1NPC1MEN1KMT2ARAB9A | |
| SCHEMBL10465406 | 0.71 | CYP3A4 (0.50) | ALOX15ALDH1A1MAPK1TDP1L3MBTL1 | |
| SCHEMBL12301896 | 0.70 | APP (0.46) | ALOX15ALDH1A1MAPK1HSP90AA1TLR9 | |
| SCHEMBL1999703 | 0.70 | ALOX15 (0.42) | ALOX15ALDH1A1MAPK1HSP90AA1TLR9 | |
| SCHEMBL29661787 | 0.70 | APP (0.46) | ALOX15ALDH1A1MAPK1HSP90AA1TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933355-A | ALDOSE REDUCTASE INHIBITORS | SANKYO COMPANY LIMITED (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0337819-A1 | Thiazole derivatives, their preparation and their use in the treatment of diabetes complications | Sankyo Company Limited (JP) | 1989-10-18 | — | — | EP | disclosed |