Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10466139 | 0.79 | RAB9A (0.46) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL24427676 | 0.79 | CXCR2 (0.38) | KDM5ANPC1MEN1KMT2ARAB9A | |
| SCHEMBL7523472 | 0.79 | SIGMAR1 (0.44) | NPC1MEN1KMT2ARAB9AHPGD | |
| SCHEMBL5434561 | 0.79 | NPC1 (0.53) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL5209247 | 0.79 | ERN1 (0.52) | KDM5ANPC1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7531866 | 0.79 | HTT (0.46) | NPC1MEN1KMT2AALOX15RAB9A | |
| SCHEMBL13167870 | 0.79 | AAK1 (0.45) | KDM5ANPC1MEN1KMT2ARAB9A | |
| SCHEMBL10465409 | 0.78 | ALOX15 (0.43) | HSP90AA1TLR9NPC1MEN1KMT2A | |
| SCHEMBL6596979 | 0.76 | MAOB (0.36) | KDM5AMEN1KMT2AALOX15SMN1; SMN2 | |
| SCHEMBL13167865 | 0.76 | ALDH1A1 (0.36) | KDM5ANPC1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933355-A | ALDOSE REDUCTASE INHIBITORS | SANKYO COMPANY LIMITED (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0337819-A1 | Thiazole derivatives, their preparation and their use in the treatment of diabetes complications | Sankyo Company Limited (JP) | 1989-10-18 | — | — | EP | disclosed |