Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | S100A4 | P26447 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7523466 | 0.79 | SIGMAR1 (0.44) | MEN1KMT2ANPC1HPGDRAB9A | |
| SCHEMBL10466138 | 0.79 | RAB9A (0.46) | MEN1KMT2ANPC1HPGDNFKB1 | |
| SCHEMBL7531861 | 0.79 | MAPK1 (0.46) | MEN1KMT2ANPC1ALOX15RAB9A | |
| SCHEMBL4726375 | 0.79 | LMNA (0.46) | MEN1KMT2ANPC1HPGDRAB9A | |
| SCHEMBL10465407 | 0.78 | ALOX15 (0.38) | HSP90AA1TLR9MEN1KMT2ANPC1 | |
| SCHEMBL6596973 | 0.76 | MAOB (0.36) | MEN1KMT2AALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL5470265 | 0.75 | P2RX4 (0.40) | MEN1KMT2ANPC1HPGDRAB9A | |
| SCHEMBL7526970 | 0.75 | KDM1A (0.39) | RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL11796056 | 0.74 | ALOX15 (0.46) | HSP90AA1TLR9MEN1KMT2ANPC1 | |
| SCHEMBL15423725 | 0.74 | ALOX15 (0.46) | HSP90AA1TLR9MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4933355-A | ALDOSE REDUCTASE INHIBITORS | SANKYO COMPANY LIMITED (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0337819-A1 | Thiazole derivatives, their preparation and their use in the treatment of diabetes complications | Sankyo Company Limited (JP) | 1989-10-18 | — | — | EP | disclosed |