Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11074836 | 0.81 | GSK3B (0.53) | GSK3BNPC1HPGDRAB9ALMNA | |
| SCHEMBL11450666 | 0.81 | NPC1 (0.53) | GSK3BNPC1HPGDRAB9ALMNA | |
| SCHEMBL1282 | 0.80 | MAPT (0.52) | GSK3BNPC1HPGDRAB9ALMNA | |
| SCHEMBL866784 | 0.79 | GSK3B (0.61) | GSK3BNPC1HPGDRAB9ALMNA | |
| SCHEMBL773970 | 0.78 | HDAC3 (0.58) | GSK3BNPC1RAB9AHDAC1HDAC8 | |
| SCHEMBL11430930 | 0.78 | GSK3B (0.59) | GSK3BNPC1HPGDRAB9ALMNA | |
| SCHEMBL11430934 | 0.76 | GSK3B (0.57) | GSK3BNPC1HPGDRAB9ALMNA | |
| SCHEMBL11430938 | 0.76 | GSK3B (0.57) | GSK3BNPC1HPGDRAB9ALMNA | |
| SCHEMBL11518309 | 0.75 | GSK3B (0.57) | GSK3BKDM4EKMT2AMAPTCES2 | |
| SCHEMBL11801259 | 0.73 | RAB9A (0.62) | GSK3BNPC1HPGDRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4051320-A | PROCESS FOR PREPARING ALKOXYLATED DERIVATIVES OF CEPHALOSPORIN COMPOUNDS | SANKYO COMPANY LIMITED (JA) | 1977-09-27 | — | — | US | claimed |
| US-4933355-A | ALDOSE REDUCTASE INHIBITORS | SANKYO COMPANY LIMITED (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0337819-A1 | Thiazole derivatives, their preparation and their use in the treatment of diabetes complications | Sankyo Company Limited (JP) | 1989-10-18 | — | — | EP | disclosed |
| US-4438265-A | Esters of 7-sulfenyliminocephem-4-carboxylic acids | SANKYO COMPANY LIMITED (JP) | 1984-03-20 | — | — | US | disclosed |
| US-4377591-A | CARBAPENICILLIN ANTIBIOTICS | SANKYO COMPANY, LIMITED (JP) | 1983-03-22 | — | — | US | disclosed |
| US-4320137-A | Derivatives of perhydro-aza-heterocycles | CIBA-GEIGY CORPORATION (US) | 1982-03-16 | — | — | US | disclosed |
| US-4247548-A | 7α-Methoxycephalosporin derivatives and their pharmaceutical compositions having antibacterial activity | SANKYO COMPANY LIMITED (JP) | 1981-01-27 | — | — | US | disclosed |
| US-4162251-A | Process for the preparation of β-lactam compounds | SANKYO COMPANY LIMITED (JP) | 1979-07-24 | — | — | US | disclosed |
| US-4160837-A | ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1979-07-10 | — | — | US | disclosed |
| US-4145344-A | BICYCLOMYCIN DERIVATIVES | CIBA-GEIGY CORPORATION (US) | 1979-03-20 | — | — | US | disclosed |
| US-4051320-A | PROCESS FOR PREPARING ALKOXYLATED DERIVATIVES OF CEPHALOSPORIN COMPOUNDS | SANKYO COMPANY LIMITED (JA) | 1977-09-27 | — | — | US | disclosed |
| US-4017488-A | Process for preparing 7β-acylamino-7α-alkoxycephalosporins | SANKYO COMPANY LIMITED (JA) | 1977-04-12 | — | — | US | disclosed |
| US-3960845-A | HALOGENATION | SANKYO COMPANY LIMITED (JA) | 1976-06-01 | — | — | US | disclosed |