Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10465854 | 0.90 | PLA2G2A (0.46) | PLA2G2AHTR6MTNR1AMTNR1BPPARG | |
| SCHEMBL10464728 | 0.90 | EGFR (0.41) | PLA2G2AHTR6EGFRIGF1RFLT4 | |
| SCHEMBL10465857 | 0.88 | CACNB4 (0.46) | HTR6TP53RXFP1XDHMAPT | |
| SCHEMBL10465576 | 0.88 | EGFR (0.45) | PLA2G2AHTR6EGFRIGF1RFLT4 | |
| SCHEMBL10465308 | 0.87 | CACNB4 (0.42) | PLA2G2AHTR6KDRPPARGPPARD | |
| SCHEMBL10465300 | 0.85 | EGFR (0.57) | PLA2G2AHTR6CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL10465887 | 0.82 | HTR6 (0.66) | HTR6 | |
| SCHEMBL10464113 | 0.82 | MTNR1A (0.52) | PLA2G2AHTR6CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL9765119 | 0.79 | CA2 (0.39) | HTR6MTNR1AMTNR1B | |
| SCHEMBL10465297 | 0.76 | EGFR (0.53) | HTR6EGFRIGF1RFLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4894387-A | RELIEF FROM PAIN FROM VASODILATION | GLAXO GROUP LIMITED (GB) | 1990-01-16 | — | — | US | disclosed |
| EP-0147107-B1 | INDOLE DERIVATES | GLAXO GROUP LIMITED (GB) | 1989-08-02 | — | — | EP | disclosed |
| EP-0147107-A1 | Indole derivates | GLAXO GROUP LIMITED (GB) | 1985-07-03 | — | — | EP | disclosed |