SCHEMBL10466635

SCHEMBL10466635

Fc1ccc(/C=C\C=C(/c2ccc(OC(F)(F)F)cc2)C2CC2)cc1Oc1ccccc1

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 2/20 0.34
RIPK1 Q13546 1/20 0.34
RIPK3 Q9Y572 1/20 0.34
PARP10 Q53GL7 1/20 0.33
MAPK14 Q16539 1/20 0.33
BRAF P15056 2/20 0.33
KDR P35968 2/20 0.33
BCHE P06276 2/20 0.32
ACHE P22303 2/20 0.32
BACE1 P56817 2/20 0.32
HSD11B1 P28845 2/20 0.32
LPAR1 Q92633 1/20 0.32
LPAR5 Q9H1C0 1/20 0.32
MGLL Q99685 3/20 0.32
SLC6A2 P23975 2/20 0.31
SLC6A4 P31645 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10466636 1.00 FFAR4 (0.34) FFAR4RIPK1RIPK3PARP10MAPK14
SCHEMBL9643228 0.89 CXCL12 (0.34) PARP10MAPK14
SCHEMBL9643233 0.89 CXCL12 (0.34) PARP10MAPK14
SCHEMBL9540404 0.88 LMNA (0.36) PARP10MGLL
SCHEMBL9540399 0.88 LMNA (0.36) PARP10MGLL
SCHEMBL9494665 0.84 PARP10 (0.36) PARP10MAPK14SLC6A2SLC6A4
SCHEMBL9494663 0.84 PARP10 (0.36) PARP10MAPK14SLC6A2SLC6A4
SCHEMBL9804217 0.83 PARP10 (0.35) PARP10MAPK14SLC6A2SLC6A4
SCHEMBL9804232 0.83 PARP10 (0.35) PARP10MAPK14SLC6A2SLC6A4
SCHEMBL9491929 0.82 PARP10 (0.34) PARP10MAPK14SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4975451-A Insecticidal cyclopropyl di(aryl) 2-butenes FMC CORPORATION (US) 1990-12-04 US disclosed