Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.55 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9135750 | 0.78 | PTGS2 (0.63) | ALOX5PTGS1PTGS2TNFRSF1ALMNA | |
| SCHEMBL8495448 | 0.77 | ALOX5 (0.65) | ALOX5PTGS1PTGS2TNFRSF1ALMNA | |
| SCHEMBL3950986 | 0.77 | SRD5A2 (0.55) | LMNAGAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL3173816 | 0.76 | ATM (0.47) | GAACA2SMN1; SMN2CA1MEN1 | |
| SCHEMBL3894279 | 0.76 | ALOX5 (0.46) | ALOX5PTGS1PTGS2TNFRSF1ALMNA | |
| SCHEMBL17935274 | 0.76 | GAA (0.51) | LMNAGAASMN1; SMN2NPSR1MEN1 | |
| SCHEMBL784936 | 0.75 | ALOX5 (0.58) | ALOX5PTGS1PTGS2TNFRSF1ALMNA | |
| SCHEMBL13328057 | 0.75 | TPMT (0.47) | LMNASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL8461116 | 0.73 | SRD5A2 (0.59) | ALOX5PTGS1PTGS2TNFRSF1ALMNA | |
| SCHEMBL13057529 | 0.73 | ALDH1A1 (0.57) | ALOX5PTGS1PTGS2TNFRSF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4935440-A | ANALGESICS, ANTIPYRETICS | SYNTEX (U.S.A.) INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4833155-A | SKIN DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1989-05-23 | — | — | US | disclosed |
| EP-0269981-A1 | 3-[alpha-(3,5-di-t-butyl-4-hydroxyphenyl)-alkanoyl]pyrroles, their de-oxy analogs, and therapeutic uses thereof | SYNTEX (U.S.A.) INC. (US) | 1988-06-08 | — | — | EP | disclosed |