SCHEMBL10469415

SCHEMBL10469415

CCCOC(=O)c1cc(C(F)(F)F)c(O)nc1NC1CCC1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR2F2 P24468 2/20 0.41
NPSR1 Q6W5P4 2/20 0.41
MAPK1 P28482 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MAPT P10636 1/20 0.41
ALDH1A1 P00352 2/20 0.40
MEN1 O00255 1/20 0.40
NPC1 O15118 1/20 0.40
S1PR2 O95136 1/20 0.40
LMNA P02545 1/20 0.40
XBP1 P17861 1/20 0.40
RAB9A P51151 1/20 0.40
PPP1CA P62136 1/20 0.40
KMT2A Q03164 1/20 0.40
SYK P43405 5/20 0.39
ULK1 O75385 2/20 0.39
MAPK8 P45983 2/20 0.35
FLT3 P36888 3/20 0.35
TYRO3 Q06418 3/20 0.35
MERTK Q12866 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10469377 0.96 NR2F2 (0.38) NR2F2NPSR1MAPK1KDM4EMAPT
SCHEMBL10468596 0.94 NR2F2 (0.39) NR2F2NPSR1MAPK1KDM4EMAPT
SCHEMBL10468535 0.91 KDM4E (0.48) NR2F2NPSR1MAPK1KDM4EMAPT
SCHEMBL10467481 0.90 ULK1 (0.37) NR2F2NPSR1MAPK1KDM4EMAPT
SCHEMBL10467342 0.89 FLT3 (0.40) SYKFLT3TYRO3MERTKGAS6
SCHEMBL10469414 0.87 NR2F2 (0.43) NR2F2NPSR1MAPK1KDM4EMAPT
SCHEMBL10468781 0.87 KDM4E (0.45) NR2F2NPSR1MAPK1KDM4EMAPT
SCHEMBL10467366 0.87 ULK1 (0.43) SYKULK1MAPK8FLT3MERTK
SCHEMBL10468313 0.86 NR2F2 (0.42) NR2F2NPSR1MAPK1KDM4EMAPT
SCHEMBL10466962 0.85 FLT3 (0.36) NR2F2NPSR1MAPK1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4916229-A Pyridine carboxylic acid derivates WARNER-LAMBERT COMPANY (US) 1990-04-10 US disclosed