Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | CFTR | P13569 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | YAP1 | P46937 | 1/20 | 0.37 |
| ▸ | WHR1 | P49842 | 1/20 | 0.37 |
| ▸ | GALR2 | O43603 | 1/20 | 0.36 |
| ▸ | GALR1 | P47211 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10468283 | 0.95 | ROCK2 (0.42) | ULK1SYKCFTRROCK2ROCK1 | |
| SCHEMBL10468535 | 0.89 | KDM4E (0.48) | ULK1SYKMAPK8 | |
| SCHEMBL10469415 | 0.87 | NR2F2 (0.41) | ULK1SYKROCK2ROCK1EGFR | |
| SCHEMBL10467039 | 0.86 | ULK1 (0.40) | ULK1SYKROCK2ROCK1EGFR | |
| SCHEMBL10466981 | 0.86 | ULK1 (0.46) | ULK1SYKMAPK8MERTK | |
| SCHEMBL10468596 | 0.85 | NR2F2 (0.39) | ULK1SYKFLT3MERTK | |
| SCHEMBL10468171 | 0.85 | ROCK2 (0.49) | SYKRIPK1ROCK2ROCK1MAPK8 | |
| SCHEMBL10469516 | 0.84 | RIPK1 (0.40) | SYKRIPK1ROCK2ROCK1MAPK8 | |
| SCHEMBL10468781 | 0.83 | KDM4E (0.45) | SYKKITFLT3 | |
| SCHEMBL10469377 | 0.81 | NR2F2 (0.38) | ULK1SYKROCK2ROCK1ULK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4916229-A | Pyridine carboxylic acid derivates | WARNER-LAMBERT COMPANY (US) | 1990-04-10 | — | — | US | disclosed |