Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10470582 | 1.00 | ATM (0.49) | ATMDRD2DRD3MEN1KMT2A | |
| Oxalic Acid SCHEMBL10677176 | 0.99 | ATM (0.50) | ATMDRD2DRD3MEN1KMT2A | |
| SCHEMBL10559479 | 0.92 | DRD2 (0.55) | ATMDRD2DRD3DPP4SIGMAR1 | |
| Oxalic Acid SCHEMBL10472959 | 0.87 | S1PR5 (0.51) | ATMDRD2DRD3SIGMAR1S1PR1 | |
| Oxalic Acid SCHEMBL10471438 | 0.81 | SLC6A12 (0.50) | DRD2DRD3MEN1KMT2ASIGMAR1 | |
| Oxalic Acid SCHEMBL10472982 | 0.80 | KDM4E (0.43) | ATMDRD2DRD3MEN1KMT2A | |
| Oxalic Acid SCHEMBL10839785 | 0.73 | S1PR5 (0.55) | ATMSIGMAR1S1PR1S1PR5KDM4E | |
| Oxalic Acid SCHEMBL10680296 | 0.73 | CHRNB2 (0.46) | — | |
| SCHEMBL10472763 | 0.72 | KMT2A (0.50) | DRD2DRD3MEN1KMT2ASIGMAR1 | |
| SCHEMBL10471617 | 0.71 | S1PR5 (0.47) | MEN1KMT2AS1PR1S1PR5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4910198-A | Antiarrhythmia agent | ORTHO PHARMACEUTICAL CORPORATION (US) | 1990-03-20 | — | — | US | disclosed |
| US-4761413-A | CYTOPROTECTION, ANTISECRETORY AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-08-02 | — | — | US | disclosed |