Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | MGMT | P16455 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10473218 | 0.91 | MEN1 (0.40) | PTPN1PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL12253970 | 0.87 | PTPN1 (0.47) | PTPN1PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL12253971 | 0.82 | ALDH1A1 (0.46) | PTPN1MAPTKMT2AALDH1A1POLB | |
| SCHEMBL14228268 | 0.80 | MGMT (0.48) | PTPN1PTGER4PTGER3PTGER2PTGER1 | |
| SCHEMBL10470640 | 0.79 | LTA4H (0.48) | PTPN1MGMTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL14450789 | 0.76 | HPGD (0.47) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL14199914 | 0.76 | HPGD (0.47) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL15679923 | 0.76 | MAPT (0.41) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL14199913 | 0.75 | MEN1 (0.53) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL14199912 | 0.75 | HPGD (0.46) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4942227-A | ANTITUMOR AGENTS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 1990-07-17 | — | — | US | disclosed |