Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4860650 | 0.82 | MAOA (0.55) | ERN1MAOAMAOBTDP1KDM4E | |
| SCHEMBL17488417 | 0.79 | ERN1 (0.53) | ERN1MAOAMAOBTDP1KDM4E | |
| Benzene SCHEMBL27502416 | 0.79 | ERN1 (0.51) | ERN1MAOAMAOBTDP1KDM4E | |
| SCHEMBL1767840 | 0.76 | MAOA (0.47) | ERN1MAOAMAOBTDP1KDM4E | |
| SCHEMBL28953244 | 0.76 | MAOA (0.52) | ERN1MAOAMAOBTDP1KDM4E | |
| SCHEMBL25213590 | 0.76 | MAOA (0.56) | MAOAMAOBTDP1KDM4EMAPT | |
| SCHEMBL9364466 | 0.75 | ERN1 (0.51) | ERN1MAOAMAOBTDP1KDM4E | |
| SCHEMBL3042274 | 0.73 | ERN1 (0.61) | ERN1MAOAMAOBTDP1KDM4E | |
| SCHEMBL10474175 | 0.72 | RXRA (0.46) | ERN1KDM4ENPSR1RXFP1KMT2A | |
| SCHEMBL28226970 | 0.72 | KDM4E (0.49) | ERN1TDP1KDM4ENPSR1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11993602-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2024-05-28 | — | — | US | disclosed |
| US-20210277009-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11993602-B2 | PRMT5 inhibitors | PRMT5, PRMT1, PRMT6 | ERN1 1232/4885MAOA 4362/4885MAOB 4206/4885 |
| US-20210277009-A1 | PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT6 | ERN1 1232/4885MAOA 4362/4885MAOB 4206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.