Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | PNLIP | P16233 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 4/20 | 0.37 |
| ▸ | MMP13 | P45452 | 4/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.37 |
| ▸ | MMP1 | P03956 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10473620 | 1.00 | PLA2G2A (0.38) | PLA2G2APNLIPMMP9MMP13ADAM17 | |
| SCHEMBL10475096 | 1.00 | PLA2G2A (0.38) | PLA2G2APNLIPMMP9MMP13ADAM17 | |
| SCHEMBL10472694 | 0.88 | PLA2G2A (0.51) | PLA2G2ATP53TSHR | |
| SCHEMBL10472667 | 0.88 | PLA2G2A (0.51) | PLA2G2ATP53TSHR | |
| SCHEMBL10474369 | 0.88 | PLA2G2A (0.51) | PLA2G2ATP53TSHR | |
| SCHEMBL9079558 | 0.83 | GPR84 (0.41) | MMP9MMP13ADAM17MMP1GPR84 | |
| SCHEMBL20802184 | 0.83 | GPR84 (0.41) | MMP9MMP13ADAM17MMP1GPR84 | |
| SCHEMBL10474112 | 0.76 | TSHR (0.39) | KDM4ETP53CYP3A4MAPTTSHR | |
| SCHEMBL10474929 | 0.76 | GPR84 (0.36) | MMP9MMP13ADAM17MMP1MMP2 | |
| SCHEMBL10528449 | 0.76 | MLYCD (0.40) | MMP9TP53TSHRMMP2GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4920221-A | CENTRAL NERVOUS SYSTEM ACTIVE AGENTS | PFIZER INC. (US) | 1990-04-24 | — | — | US | disclosed |
| US-4642373-A | Substituted dodecahydrotripheylenes, and decahydropyrrolo[1,2-f]phenanthridines as CNS agents | PFIZER INC. (US) | 1987-02-10 | — | — | US | disclosed |
| US-4576964-A | ANALGESICS, ANTIEMETICS | PFIZER INC. (US) | 1986-03-18 | — | — | US | disclosed |
| US-4476131-A | ANTIEMETICS, ANALGESICS | PFIZER INC. (US) | 1984-10-09 | — | — | US | disclosed |
| US-4473704-A | ANALGESICS, ANTIEMETICS | PFIZER INC. (US) | 1984-09-25 | — | — | US | disclosed |