Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 8/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | ALPI | P09923 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | ALPG | P10696 | 1/20 | 0.59 |
| ▸ | APEX1 | P27695 | 1/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | CASP6 | P55212 | 1/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.59 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7685854 | 0.89 | NPC1 (0.68) | HSD17B3NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL11090894 | 0.87 | HSD17B3 (0.66) | HSD17B3NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL22546667 | 0.85 | HSD17B3 (0.58) | HSD17B3NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4938426 | 0.84 | KMT2A (0.60) | NPC1RAB9AALDH1A1POLBTRPA1 | |
| SCHEMBL17032601 | 0.82 | NPC1 (0.62) | NPC1RAB9AKDM4EALDH1A1TRPA1 | |
| SCHEMBL7426211 | 0.82 | TRPA1 (0.54) | NPC1RAB9APOLBL3MBTL1TRPA1 | |
| SCHEMBL2850064 | 0.82 | TRPA1 (0.54) | ALDH1A1POLBTRPA1USP5 | |
| SCHEMBL725762 | 0.82 | TRPA1 (0.58) | NPC1RAB9AKDM4EALDH1A1POLB | |
| Benzene SCHEMBL27311002 | 0.82 | TRPA1 (0.58) | NPC1RAB9AKDM4EALDH1A1POLB | |
| SCHEMBL15656585 | 0.81 | TRPA1 (0.53) | HSD17B3NPC1RAB9AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109627232-B | Quinoline compound and preparation method and application thereof | 广东环境保护工程职业学院 | 2021-02-09 | — | — | CN | claimed |
| CN-109384766-B | Quinoline compound and preparation method and application thereof | 广东环境保护工程职业学院 | 2021-02-09 | — | — | CN | claimed |
| CN-115515685-B | EIF4E inhibitors and uses thereof | 皮克医疗公司 | 2025-04-08 | — | — | CN | disclosed |
| US-12157731-B2 | EIF4E inhibitors and uses thereof | PIC Therapeutics, Inc. (US) | 2024-12-03 | — | — | US | disclosed |
| US-20230399322-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. | 2023-12-14 | — | — | US | disclosed |
| US-20230399322-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. | 2023-12-14 | — | — | US | disclosed |
| US-20230399322-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. | 2023-12-14 | — | — | US | disclosed |
| US-11753403-B2 | EIF4E inhibitors and uses thereof | PIC Therapeutics, Inc. (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753403-B2 | EIF4E inhibitors and uses thereof | PIC Therapeutics, Inc. (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753403-B2 | EIF4E inhibitors and uses thereof | PIC Therapeutics, Inc. (US) | 2023-09-12 | — | — | US | disclosed |
| EP-4114529-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. (US) | 2023-01-11 | — | — | EP | disclosed |
| CN-115515685-A | EIF4E inhibitor and application thereof | 皮克医疗公司 | 2022-12-23 | — | — | CN | disclosed |
| US-20220356178-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. | 2022-11-10 | — | — | US | disclosed |
| WO-2021178488-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. (US) | 2021-09-10 | — | — | WO | disclosed |
| WO-2021178488-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. (US) | 2021-09-10 | — | — | WO | disclosed |
| CN-109384766-B | Quinoline compound and preparation method and application thereof | 广东环境保护工程职业学院 | 2021-02-09 | — | — | CN | disclosed |
| CN-109627232-B | Quinoline compound and preparation method and application thereof | 广东环境保护工程职业学院 | 2021-02-09 | — | — | CN | disclosed |
| WO-1990013535-A1 | COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230399322-A1 | EIF4E INHIBITORS AND USES THEREOF | EIF4E, EIF4EBP1, EIF4A1 | HSD17B3 4287/4885NPC1 2317/4885RAB9A 1568/4885 |
| US-12157731-B2 | EIF4E inhibitors and uses thereof | EIF4E, EIF4EBP1, EIF4A1 | HSD17B3 4287/4885NPC1 2317/4885RAB9A 1568/4885 |
| US-11753403-B2 | EIF4E inhibitors and uses thereof | EIF4E, EIF4EBP1, EIF4A1 | HSD17B3 4287/4885NPC1 2317/4885RAB9A 1568/4885 |
| US-20220356178-A1 | EIF4E INHIBITORS AND USES THEREOF | EIF4E, EIF4EBP1, EIF4A1 | HSD17B3 4287/4885NPC1 2317/4885RAB9A 1568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.