Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 3/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13958462 | 0.89 | FDPS (0.56) | FDPSGSK3BF3APPMAOB | |
| SCHEMBL5750014 | 0.88 | THRB (0.59) | GSK3BF3MAOBTHRBATM | |
| SCHEMBL7663462 | 0.88 | THRB (0.59) | GSK3BF3MAOBTHRBATM | |
| SCHEMBL20943613 | 0.88 | GSK3B (0.51) | FDPSGSK3BF3APPMAOB | |
| SCHEMBL20943614 | 0.88 | GSK3B (0.51) | FDPSGSK3BF3APPMAOB | |
| SCHEMBL12577549 | 0.83 | CA12 (0.57) | FDPSAPPMAOBTDP1TAS1R3 | |
| SCHEMBL16171985 | 0.82 | MAPT (0.67) | MAOBABCG2PPARA | |
| SCHEMBL25238725 | 0.81 | XDH (0.65) | F3MAOBABCG2IKBKBRARA | |
| SCHEMBL2832894 | 0.80 | AHR (0.41) | APPCTNNB1 | |
| SCHEMBL5751632 | 0.79 | CTNNB1 (0.39) | APPCTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4859664-A | Derivatives of 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonines and -1,4-benzoxazonines, processes for their production and their use as pharmaceuticals | MADAUS GMBH & COMPANY (DE) | 1989-08-22 | — | — | US | disclosed |