Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.51 |
| ▸ | SOD1 | P00441 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10485667 | 0.99 | HTR7 (0.62) | HTR7MAPTSMN1; SMN2LMNAKCNH2 | |
| SCHEMBL10486108 | 0.90 | MAPT (0.56) | HTR7MAPTSMN1; SMN2ABCB1MAPK1 | |
| SCHEMBL10486115 | 0.88 | HTR7 (0.80) | HTR7MAPTSMN1; SMN2LMNAKCNH2 | |
| SCHEMBL10486189 | 0.86 | KCNH2 (0.70) | HTR7MAPTSMN1; SMN2LMNAKCNH2 | |
| SCHEMBL10486120 | 0.85 | MAPT (0.65) | HTR7MAPTSMN1; SMN2LMNAKCNH2 | |
| Hydrochloric Acid SCHEMBL10485620 | 0.85 | KCNH2 (0.68) | HTR7MAPTSMN1; SMN2LMNAKCNH2 | |
| Hydrochloric Acid SCHEMBL10485594 | 0.84 | MAPT (0.64) | HTR7MAPTSMN1; SMN2LMNAKCNH2 | |
| SCHEMBL10485775 | 0.83 | MAPT (0.79) | HTR7MAPTSMN1; SMN2LMNAKCNH2 | |
| Hydrochloric Acid SCHEMBL10485836 | 0.82 | MAPT (0.77) | HTR7MAPTSMN1; SMN2LMNAKCNH2 | |
| SCHEMBL10700125 | 0.81 | HTR1A (0.67) | HTR7MAPTSMN1; SMN2KCNH2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882330-A | 1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0269383-A2 | 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-06-01 | — | — | EP | disclosed |