Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 17/20 | 0.43 |
| ▸ | PPARA | Q07869 | 15/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9818873 | 0.85 | PPARG (0.46) | PPARGPPARALDHA | |
| SCHEMBL11292923 | 0.77 | PPARG (0.50) | PPARGPPARA | |
| SCHEMBL10487454 | 0.76 | RAB9A (0.51) | PPARGPPARA | |
| SCHEMBL27617197 | 0.76 | SIGMAR1 (0.46) | SLC6A4 | |
| SCHEMBL106764 | 0.75 | EPHX1 (0.44) | SLC6A4 | |
| SCHEMBL11757844 | 0.75 | PPARG (0.42) | PPARGPPARA | |
| SCHEMBL11659888 | 0.75 | TSHR (0.39) | PPARGPPARASLC6A4 | |
| SCHEMBL9818821 | 0.73 | PPARG (0.76) | PPARGPPARA | |
| SCHEMBL7001784 | 0.73 | MAOA (0.53) | PPARGPPARA | |
| SCHEMBL10487481 | 0.72 | PPARG (0.61) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| WO-1987004344-A1 | HYDROXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1987-07-30 | — | — | WO | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |