Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 10/20 | 0.67 |
| ▸ | HTR7 | P34969 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29808213 | 1.00 | MAPKAPK2 (0.67) | MAPKAPK2HTR7CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1491406 | 0.86 | MAPKAPK2 (0.71) | MAPKAPK2HTR7CYP3A4CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL28201946 | 0.85 | MAPKAPK2 (0.70) | MAPKAPK2HTR7CYP3A4CYP2D6CYP2C19 | |
| Acetone SCHEMBL27932467 | 0.84 | MAPKAPK2 (0.68) | MAPKAPK2HTR7CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL273473 | 0.83 | MAPKAPK2 (0.67) | MAPKAPK2HTR7CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL10481507 | 0.83 | MAPKAPK2 (0.67) | MAPKAPK2HTR7CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9696707 | 0.82 | MAPKAPK2 (0.77) | MAPKAPK2HTR7CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11128610 | 0.81 | MAPKAPK2 (0.54) | MAPKAPK2HTR7CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL7267623 | 0.81 | MAPKAPK2 (0.67) | MAPKAPK2HTR7CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL21465236 | 0.80 | MAPKAPK2 (1.00) | MAPKAPK2HTR7CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4826855-A | Thieno pyridines and their use as anti-hypertensive agents | BOEHRINGER INGELHEIM KG (DE) | 1989-05-02 | — | — | US | disclosed |
| US-4766129-A | Pyrrolo[2,3-C]pyridines and their use as anti-hypertensive agents | BOEHRINGER INGELHEIM KG (DE) | 1988-08-23 | — | — | US | disclosed |
| US-4683238-A | 2,3,4,9-tetrahydro beta carboline derivatives, useful as antihypertensive agents | BOEHRINGER INGELHEIM KG (DE) | 1987-07-28 | — | — | US | disclosed |
| US-4555511-A | Thieno [3,2,C]pyridines useful as antihypertensives | BOEHRINGER INGELHEIM KG (DE) | 1985-11-26 | — | — | US | disclosed |