Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.71 |
| ▸ | HTR7 | P34969 | 3/20 | 0.55 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.53 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28201946 | 0.99 | MAPKAPK2 (0.70) | MAPKAPK2HTR7MAPKAPK5KDM4EHSD17B10 | |
| Acetone SCHEMBL27932467 | 0.97 | MAPKAPK2 (0.68) | MAPKAPK2HTR7MAPKAPK5KDM4EHSD17B10 | |
| SCHEMBL10489357 | 0.86 | MAPKAPK2 (0.67) | MAPKAPK2HTR7MAPKAPK5CYP2D6CYP2C19 | |
| SCHEMBL273473 | 0.86 | MAPKAPK2 (0.67) | MAPKAPK2HTR7MAPKAPK5KDM4EHSD17B10 | |
| SCHEMBL29808213 | 0.86 | MAPKAPK2 (0.67) | MAPKAPK2HTR7MAPKAPK5CYP2D6CYP2C19 | |
| SCHEMBL10481507 | 0.86 | MAPKAPK2 (0.67) | MAPKAPK2HTR7MAPKAPK5KDM4EHSD17B10 | |
| SCHEMBL9696707 | 0.85 | MAPKAPK2 (0.77) | MAPKAPK2HTR7MAPKAPK5CYP2D6CYP2C19 | |
| SCHEMBL14924843 | 0.84 | MAPKAPK2 (0.77) | MAPKAPK2MAPKAPK5 | |
| SCHEMBL1491320 | 0.83 | MAPKAPK2 (1.00) | MAPKAPK2HTR7MAPKAPK5CYP2D6CYP2C19 | |
| SCHEMBL21465236 | 0.83 | MAPKAPK2 (1.00) | MAPKAPK2HTR7MAPKAPK5CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105753860-A | Beta-carboline alkaloid and application thereof in preparation of antitumor drugs | 兰州大学 | 2016-07-13 | — | — | CN | claimed |
| CN-103450340-B | The antineoplastic oligopeptide that heterocyclic carboxylic acid is modified, its synthesis, antitumor action and application | Capital Medical University (CN) | 2015-08-05 | — | — | CN | claimed |
| CN-103450340-A | Heterocyclic carboxylic acid-modified anti-tumor oligopeptides and their synthesis, anti-tumor effects and application | UNIV CAPITAL MEDICAL SCIENCES | 2013-12-18 | — | — | CN | claimed |
| CN-103450338-A | Heterocyclic carboxylic acid-modified thymopentins and their preparation method, anti-tumor effect and use | UNIV CAPITAL MEDICAL SCIENCES | 2013-12-18 | — | — | CN | claimed |
| EP-0273321-B1 | 7-BROMO-BETA-CARBOLINE COMPOUND AND METHOD FOR PRODUCING SAME | Kawaken Fine Chemicals Co., Ltd. (JP) | 1992-04-22 | — | — | EP | claimed |
| US-4894457-A | BROMINATION, HYDROLYSIS | KAWAKEN FINE CHEMICALS CO., LTD. (JP) | 1990-01-16 | — | — | US | claimed |
| EP-0273321-A1 | 7-Bromo-beta-carboline compound and method for producing same | Kawaken Fine Chemicals Co., Ltd. (JP) | 1988-07-06 | — | — | EP | claimed |
| CN-111303148-B | 1-substituted beta-carboline derivatives and application thereof | 南京农业大学 | 2022-08-30 | — | — | CN | disclosed |
| CN-111303148-A | 1-substituted β -carboline derivatives and application thereof | 南京农业大学 | 2020-06-19 | — | — | CN | disclosed |
| CN-105753860-A | Beta-carboline alkaloid and application thereof in preparation of antitumor drugs | 兰州大学 | 2016-07-13 | — | — | CN | disclosed |
| US-9133104-B2 | Enzyme inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2015-09-15 | — | — | US | disclosed |
| US-9133104-B2 | Enzyme inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2015-09-15 | — | — | US | disclosed |
| CN-103450340-B | The antineoplastic oligopeptide that heterocyclic carboxylic acid is modified, its synthesis, antitumor action and application | Capital Medical University (CN) | 2015-08-05 | — | — | CN | disclosed |
| US-20090291978-A1 | Enzyme Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2009-11-26 | — | — | US | disclosed |
| US-20090291978-A1 | Enzyme Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2009-11-26 | — | — | US | disclosed |
| EP-1879895-A1 | ENZYME INHIBITORS | Chroma Therapeutics Limited (GB) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006117549-A1 | ENZYME INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2006-11-09 | — | — | WO | disclosed |
| EP-0273321-B1 | 7-BROMO-BETA-CARBOLINE COMPOUND AND METHOD FOR PRODUCING SAME | Kawaken Fine Chemicals Co., Ltd. (JP) | 1992-04-22 | — | — | EP | disclosed |
| US-4894457-A | BROMINATION, HYDROLYSIS | KAWAKEN FINE CHEMICALS CO., LTD. (JP) | 1990-01-16 | — | — | US | disclosed |
| EP-0273321-A1 | 7-Bromo-beta-carboline compound and method for producing same | Kawaken Fine Chemicals Co., Ltd. (JP) | 1988-07-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291978-A1 | Enzyme Inhibitors | HAT1, NR2E1, NR2C2 | MAPKAPK2 1644/4885HTR7 2101/4885MAPKAPK5 1955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.