Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10481507 | 1.00 | MAPKAPK2 (0.67) | MAPKAPK2KDM4EALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL1491406 | 0.86 | MAPKAPK2 (0.71) | MAPKAPK2KDM4EALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL5534250 | 0.86 | MAPKAPK2 (0.67) | MAPKAPK2CYP2D6CYP2C19HTR7CYP3A4 | |
| Hydrochloric Acid SCHEMBL28201946 | 0.85 | MAPKAPK2 (0.70) | MAPKAPK2KDM4EALDH1A1CYP2D6CYP2C19 | |
| Acetone SCHEMBL27932467 | 0.84 | MAPKAPK2 (0.68) | MAPKAPK2KDM4EALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL23070186 | 0.84 | MAPKAPK2 (0.69) | MAPKAPK2KDM4EMAPKAPK5KMT2A | |
| SCHEMBL28652272 | 0.84 | MAPKAPK2 (0.69) | MAPKAPK2MAPKAPK5KMT2A | |
| SCHEMBL30923475 | 0.84 | MAPKAPK2 (0.69) | MAPKAPK2MAPKAPK5KMT2A | |
| SCHEMBL9687220 | 0.84 | MAPKAPK2 (0.50) | MAPKAPK2KDM4EALDH1A1MAPKAPK5KMT2A | |
| SCHEMBL10489357 | 0.83 | MAPKAPK2 (0.67) | MAPKAPK2CYP2D6CYP2C19HTR7CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117362291-A | Tetrahydro-beta-carboline phenol derivative, preparation method and application thereof, and whitening cream | 广州番禺职业技术学院 | 2024-01-09 | — | — | CN | claimed |
| CN-117362291-A | Tetrahydro-beta-carboline phenol derivative, preparation method and application thereof, and whitening cream | 广州番禺职业技术学院 | 2024-01-09 | — | — | CN | disclosed |
| US-8133992-B2 | Azepinoindole and pyridoindole derivatives as pharmaceutical agents | EXELIXIS, INC. (US) | 2012-03-13 | — | — | US | disclosed |
| EP-1532153-B1 | AZEPINOINDOLE AND PYRIDOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | X CEPTOR THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| US-20090326218-A1 | Azepinoindole and Pyridoindole Derivatives as Pharmaceutical Agents | EXELIXIS, INC. (US) | 2009-12-31 | — | — | US | disclosed |
| US-7485634-B2 | Azepinoindole and pyridoindole derivatives as pharmaceutical agents | EXELIXIS, INC. (US) | 2009-02-03 | — | — | US | disclosed |
| EP-1532153-A1 | AZEPINOINDOLE AND PYRIDOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | X-Ceptor Therapeutics, Inc. (US) | 2005-05-25 | — | — | EP | disclosed |
| US-20040023947-A1 | Azepinoindole and pyridoindole derivatives as pharmaceutical agents | X-CEPTOR THERAPEUTICS INC. | 2004-02-05 | — | — | US | disclosed |
| WO-2003099821-A1 | AZEPINOINDOLE AND PYRIDOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | X-CEPTOR THERAPEUTICS, INC. (US) | 2003-12-04 | — | — | WO | disclosed |
| US-4358451-A | ANOXIA, PSYCHOTROPIC | SYNTHELABO (FR) | 1982-11-09 | — | — | US | disclosed |
| US-4336256-A | TREATMENT OF ANOXIA, DEPRESSION AND IN PSYCHOTROPIC THERAPY | SYNTHELABO (FR) | 1982-06-22 | — | — | US | disclosed |
| US-4272539-A | ANOXIA, ANTIDEPRESSANTS | SYNTHELABO (FR) | 1981-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040023947-A1 | Azepinoindole and pyridoindole derivatives as pharmaceutical agents | HTR5A, MTNR1A, PTGDR | MAPKAPK2 1349/4885KDM4E 4534/4885ALDH1A1 1722/4885 |
| US-20090326218-A1 | Azepinoindole and Pyridoindole Derivatives as Pharmaceutical Agents | HTR5A, MTNR1A, PTGDR | MAPKAPK2 1349/4885KDM4E 4534/4885ALDH1A1 1722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.