Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | P4HB | P07237 | 2/20 | 0.47 |
| ▸ | EDNRA | P25101 | 2/20 | 0.47 |
| ▸ | EDNRB | P24530 | 1/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10490943 | 0.85 | HDAC4 (0.47) | HPGDP4HBHDAC4HDAC8 | |
| SCHEMBL10490935 | 0.81 | HDAC4 (0.46) | NPC1MAPTRAB9ASMN1; SMN2HDAC4 | |
| SCHEMBL9421974 | 0.80 | ALDH1A1 (0.47) | MAPTHPGDMAOASMN1; SMN2EDNRA | |
| SCHEMBL10490976 | 0.77 | MEN1 (0.54) | TP53MAPTHPGDP4HB | |
| SCHEMBL8062512 | 0.76 | P4HB (0.42) | MAPTP4HBCCNE2CDK4CCND1 | |
| SCHEMBL9178368 | 0.75 | ALDH1A1 (0.52) | NPC1MAPTRAB9AP4HBHDAC4 | |
| SCHEMBL8077882 | 0.75 | HTT (0.42) | NPC1HPGDRAB9ASMN1; SMN2P4HB | |
| SCHEMBL8062515 | 0.74 | P4HB (0.41) | P4HBCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL28611915 | 0.73 | P4HB (0.40) | P4HBCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL8063601 | 0.73 | NFKB1 (0.50) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4843097-A | ANTITUMOR AGENTS, SKIN DISORDERS, ANTIINFLAMMATORY AGENTS | GROUPEMENT D'INTERET ECONOMIQUE DIT: CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) | 1989-06-27 | — | — | US | claimed |
| US-4889865-A | COSMETICS, SKIN DISORDERS, ANTICARCINOGENIC AGENTS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) | 1989-12-26 | — | — | US | disclosed |
| US-4843097-A | ANTITUMOR AGENTS, SKIN DISORDERS, ANTIINFLAMMATORY AGENTS | GROUPEMENT D'INTERET ECONOMIQUE DIT: CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) | 1989-06-27 | — | — | US | disclosed |