SCHEMBL10490983

SCHEMBL10490983

CCCCCC1c2cccc(O)c2C(=O)c2c(O)cccc21

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.63
ELANE P08246 3/20 0.52
CTSG P08311 3/20 0.52
P4HB P07237 1/20 0.46
ALDH1A1 P00352 2/20 0.44
MAPT P10636 2/20 0.44
HTT P42858 2/20 0.44
LMNA P02545 1/20 0.44
HPGD P15428 1/20 0.44
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44
MAOA P21397 1/20 0.44
MAOB P27338 1/20 0.44
MAPK1 P28482 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
HSD17B10 Q99714 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
ATM Q13315 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10630402 0.88 CES2 (0.52) CES2ELANECTSGMAPTLMNA
SCHEMBL10634752 0.86 CES2 (0.50) CES2ELANECTSGALDH1A1MAPT
SCHEMBL8624814 0.85 ELANE (0.52) CES2ELANECTSG
SCHEMBL8077270 0.81 CES2 (0.50) CES2ELANECTSG
SCHEMBL9629596 0.80 CES2 (0.51) CES2ELANECTSGP4HB
SCHEMBL9628696 0.80 CES2 (0.51) CES2ELANECTSGP4HB
SCHEMBL9700567 0.79 CES2 (0.52) CES2ALDH1A1MAPTHTTMEN1
SCHEMBL9185267 0.77 L3MBTL1 (0.53) MAPTLMNATDP1
SCHEMBL11292310 0.76 CES2 (0.47) CES2ELANECTSGALDH1A1MAPT
SCHEMBL9182611 0.76 L3MBTL1 (0.50) MAPTLMNATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4889865-A COSMETICS, SKIN DISORDERS, ANTICARCINOGENIC AGENTS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) 1989-12-26 US claimed
US-4843097-A ANTITUMOR AGENTS, SKIN DISORDERS, ANTIINFLAMMATORY AGENTS GROUPEMENT D'INTERET ECONOMIQUE DIT: CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) 1989-06-27 US claimed
EP-0017420-B1 NEW DIHYDROXY-ACYLANTHRONES HAVING ANTI-PSORIATIC ACTIVITY, PROCESS FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THEIR USE AS ANTI-PSORIATIC AGENTS ORION-YHTYMÄ OY (FI) 1982-07-21 EP claimed
US-4299846-A Dihydroxy-acylanthrones having anti-psoriatic activity ORION-YHTYMA OY (FI) 1981-11-10 US claimed
EP-0017420-A1 New dihydroxy-acylanthrones having anti-psoriatic activity, process for preparing them, pharmaceutical compositions comprising them, and their use as anti-psoriatic agents ORION-YHTYMÄ OY (FI) 1980-10-15 EP claimed
US-4889865-A COSMETICS, SKIN DISORDERS, ANTICARCINOGENIC AGENTS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) 1989-12-26 US disclosed
US-4889865-A COSMETICS, SKIN DISORDERS, ANTICARCINOGENIC AGENTS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) 1989-12-26 US disclosed
US-4843097-A ANTITUMOR AGENTS, SKIN DISORDERS, ANTIINFLAMMATORY AGENTS GROUPEMENT D'INTERET ECONOMIQUE DIT: CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) 1989-06-27 US disclosed
US-4843097-A ANTITUMOR AGENTS, SKIN DISORDERS, ANTIINFLAMMATORY AGENTS GROUPEMENT D'INTERET ECONOMIQUE DIT: CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) 1989-06-27 US disclosed
US-4755530-A 1-hydroxy-8-acyloxy-10-acyl anthrones, process for their preparation and their use in human or veterinary medicines and in cosmetic formulations CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D) (FR) 1988-07-05 US disclosed
US-4696941-A SKIN DISORDERS, ANTIINFLAMMATORY AGENTS Groupement d'Interet Economique dit: Centre International 'de Recherches Dermatologiques C.I.R.D. (FR) 1987-09-29 US disclosed
EP-0017420-B1 NEW DIHYDROXY-ACYLANTHRONES HAVING ANTI-PSORIATIC ACTIVITY, PROCESS FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THEIR USE AS ANTI-PSORIATIC AGENTS ORION-YHTYMÄ OY (FI) 1982-07-21 EP disclosed
US-4299846-A Dihydroxy-acylanthrones having anti-psoriatic activity ORION-YHTYMA OY (FI) 1981-11-10 US disclosed
US-4299846-A Dihydroxy-acylanthrones having anti-psoriatic activity ORION-YHTYMA OY (FI) 1981-11-10 US disclosed
EP-0017420-A1 New dihydroxy-acylanthrones having anti-psoriatic activity, process for preparing them, pharmaceutical compositions comprising them, and their use as anti-psoriatic agents ORION-YHTYMÄ OY (FI) 1980-10-15 EP disclosed
EP-0017420-A1 New dihydroxy-acylanthrones having anti-psoriatic activity, process for preparing them, pharmaceutical compositions comprising them, and their use as anti-psoriatic agents ORION-YHTYMÄ OY (FI) 1980-10-15 EP disclosed