SCHEMBL1049841

SCHEMBL1049841

FC(F)(F)[Si](c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.41
TSHR P16473 1/20 0.41
NR1H2 P55055 3/20 0.39
NR1H3 Q13133 3/20 0.39
ESR1 P03372 1/20 0.37
ESR2 Q92731 1/20 0.37
KIF11 P52732 1/20 0.35
POLB P06746 1/20 0.34
CES1 P23141 2/20 0.33
PKM P14618 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
PTPN1 P18031 1/20 0.32
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA5A P35218 1/20 0.31
CA9 Q16790 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29054459 0.78 NR1H2 (0.45) ALDH1A1TSHRNR1H2NR1H3ESR1
SCHEMBL1053231 0.77 ALDH1A1 (0.41) ALDH1A1TSHRNR1H2NR1H3ESR1
SCHEMBL1051334 0.77 ALDH1A1 (0.41) ALDH1A1TSHRNR1H2NR1H3ESR1
SCHEMBL1054533 0.74 ACHE (0.44) ALDH1A1TSHRCA1CA2CA5A
SCHEMBL23701150 0.72 TSHR (0.38) ALDH1A1TSHRNR1H2NR1H3ESR1
SCHEMBL21438997 0.72 TSHR (0.38) ALDH1A1TSHRNR1H2NR1H3ESR1
SCHEMBL23701389 0.72 ALDH1A1 (0.38) ALDH1A1TSHRNR1H2NR1H3ESR1
SCHEMBL104796 0.72 NR1H2 (0.45) ALDH1A1TSHRNR1H2NR1H3ESR1
SCHEMBL3526796 0.71 ESR1 (0.37) ALDH1A1TSHRNR1H2NR1H3ESR1
SCHEMBL703156 0.69 ESR1 (0.40) ALDH1A1TSHRNR1H2NR1H3ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117303991-A 4-trifluoromethyl substituted aromatic amine and synthesis method thereof 江苏笃行致远新材料科技有限公司 2023-12-29 CN claimed
CN-117303991-A 4-trifluoromethyl substituted aromatic amine and synthesis method thereof 江苏笃行致远新材料科技有限公司 2023-12-29 CN disclosed
EP-3141538-B1 IMPROVED PROCESS STABILITY OF NBDE USING SUBSTITUTED PHENOL STABILIZERS VERSUM MAT US LLC (US) 2019-10-30 EP disclosed
EP-2318477-B1 ADDITIVES TO PREVENT DEGRADATION OF CYCLIC ALKENE DERIVATIVES FUJIFILM ELECTRONIC MAT USA INC (US) 2019-06-05 EP disclosed
EP-3141538-A1 IMPROVED PROCESS STABILITY OF NBDE USING SUBSTITUTED PHENOL STABILIZERS AIR PRODUCTS AND CHEMICALS, INC. (US) 2017-03-15 EP disclosed
EP-2141141-B1 Improved Process Stability of NBDE Using Substituted Phenol Stabilizers AIR PROD & CHEM (US) 2016-09-28 EP disclosed
EP-1931613-B1 ADDITIVES TO PREVENT DEGRADATION OF CYCLIC ALKENE DERIVATIVES FUJIFILM ELECTRONIC MATERIALS (US) 2015-11-11 EP disclosed
CN-102089405-B Additives to prevent degradation of cyclic alkene derivatives FUJIFILM ELECTRONIC MATERIALS 2013-10-16 CN disclosed
EP-1931746-B1 ADDITIVES TO PREVENT DEGRADATION OF CYCLIC ALKENE DERIVATIVES FUJIFILM ELECTRONIC MATERIALS (US) 2013-09-04 EP disclosed
US-8252704-B2 Additives to prevent degradation of cyclic alkene derivatives FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. (US) 2012-08-28 US disclosed
US-20070057235-A1 Additives to prevent degradation of cyclic alkene derivatives FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. 2007-03-15 US disclosed
US-5302752-A Acetic acid derivatives and their production ETHYL CORPORATION (US) 1994-04-12 US disclosed
EP-0426333-A2 Acetic acid derivatives and their production ETHYL CORPORATION (US) 1991-05-08 EP disclosed
US-5008425-A Trifluoromethylation of carbonyl compounds ETHYL CORPORATION (US) 1991-04-16 US disclosed
EP-0336371-A2 Gem-disubstituted cyclohexadienones and their production ETHYL CORPORATION (US) 1989-10-11 EP disclosed
US-4871877-A Gem-disubstituted cyclohexadienones and their production ETHYL CORPORATION (US) 1989-10-03 US disclosed
US-4845258-A Production of gem-disubstituted cyclohexadienones ETHYL CORPORATION (US) 1989-07-04 US disclosed
US-4804774-A Production of gem-disubstituted cyclohexadienones ETHYL CORPORATION (US) 1989-02-14 US disclosed
US-4804772-A Gem-disubstituted cyclohexadienones and their production ETHYL CORPORATION (US) 1989-02-14 US disclosed
US-4804773-A Production of gem-disubstituted cyclohexadienones ETHYL CORPORATION (US) 1989-02-14 US disclosed