Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10499621 | 0.76 | TAS1R3 (0.39) | NPSR1KDM4EALDH1A1GAASCN4A | |
| SCHEMBL12412401 | 0.75 | GABRA1 (0.47) | GAASCN4A | |
| Hydrochloric Acid SCHEMBL11040671 | 0.75 | SCN4A (0.33) | ALDH1A1GAASCN4A | |
| SCHEMBL28660489 | 0.74 | ERN1 (0.49) | TSHRBLMNPSR1KDM4EALDH1A1 | |
| SCHEMBL28666073 | 0.74 | ERN1 (0.49) | TSHRBLMNPSR1KDM4EALDH1A1 | |
| SCHEMBL10500124 | 0.74 | SCN4A (0.34) | SCN4A | |
| SCHEMBL1572909 | 0.74 | TSHR (0.49) | TSHRBLMNPSR1ALDH1A1 | |
| SCHEMBL1572907 | 0.74 | TSHR (0.49) | TSHRBLMNPSR1ALDH1A1 | |
| SCHEMBL654108 | 0.73 | TSHR (0.50) | TSHRHTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL1988952 | 0.73 | KDM4E (0.54) | KDM4EALDH1A1TPMTGAAMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0117035-B1 | ALDOSE REDUCTASE INHIBITING 5-(2-ALKOXYPHENYL)THIAZOLIDINEDIONES | PFIZER INC. (US) | 1989-08-16 | — | — | EP | disclosed |
| US-4617312-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1986-10-14 | — | — | US | disclosed |
| EP-0117035-A2 | Aldose reductase inhibiting 5-(2-alkoxyphenyl)thiazolidinediones | PFIZER INC. (US) | 1984-08-29 | — | — | EP | disclosed |